Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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Citations
The excitatory effect of nitric oxide on carotid body chemoreception is blocked by oligomycin.
TL;DR: It has been proposed that nitric oxide (NO) is a tonic inhibitory modulator of chemoreception to hypoxia and this proposition is based on the immunocytochemical localization of NO synthase (NOS) in autonomic neurons10,20, and petrosal C sensory fibers.
1
Reactive Oxygen and Nitrogen Species: Activating Signals in Inflammation
J. Steven Alexander,Matthew B. Grisham,F. Stephen Laroux +2 more
- 01 Jan 2003
TL;DR: Reactive oxygen and nitrogen species have since gained recognition as important intra- and intercellular signalling molecules in both normal as well as pathological conditions and may represent a novel class of second or third messengers.
1
Trichomonas vaginalis and Giardia intestinalis produce nitric oxide.
Kristina M. Harris,Burt Goldberg,Giancarlo A. Biagini,David Lloyd +3 more
- 01 Mar 2007
TL;DR: In this article, it was shown that trichomonas vaginalis produces Nitric Oxide (NO) from the host's immune system, and provided evidence about its cytotoxic manifestations in the parasites.
1
•Dissertation
NO- and CO-mediated inhibition of mitochondrial respiration in activated macrophages.
Francis King Wan Lam
- 01 Jan 2005
TL;DR: The effects of respiratory inhibition were investigated with regards to the stability of Hypoxia-induced hypoxia inducible factor la (HTFla), which resulted in the stabilisation of HIFla protein, a phenomenon that was prevented by inhibition of the ETC at various complexes.
References
•Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
1.6K
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
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Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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