Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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Nitric oxide: physiology, pathophysiology, and pharmacology
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
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Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
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Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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