Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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Citations
89 – Role of Oxidative Stress in Alcohol-Induced Mitochondrial Dysfunction
S.M. Bailey
- 01 Jan 2004
TL;DR: This chapter addresses the critical role of reactive oxygen and nitrogen species in alcohol-induced liver injury with specific emphasis on the mechanisms by which alcohol stimulates the production of these reactive species in mitochondria and the way their production negatively impacts mitochondrial function and disrupts hepatic energy conservation.
2
Short communication Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention
Eva Szabob
- 01 Jan 2003
TL;DR: Peroxynitrite is a powerful oxidant exhibiting a wide array of tissue damaging effects ranging from lipid peroxidation, inactivation of enzymes and ion channels via protein oxidation and nitration to inhibition of mitochondrial respiration.
2
Mitochondrial oxidative stress and metabolic alterations in neurodegenerative disorders
TL;DR: Because mitochondria are involved in both calcium and ROS homeostasis, it is likely that they play a pivotal role in mediating neuron death.
2
Effects of Tamoxifen on Mitochondrial NOS activity: alteration in the intramitochondrial Ca2+ homeostasis
Sandeep S. Joshi
- 01 Jan 2005
TL;DR: A chronology of key events and figures leading up to and including the invention of the atomic bombs in World War Two are described.
Thyroid hormones and heart mitochondrial nitric oxide under hypovolemia
Natalia Ogonowski,Laura B. Valdez,Tamara Zaobornyj,María Bernardita Puchulu,Ana M. Balaszczuk,Andrea L. Fellet +5 more
TL;DR: Experimental studies of the laboratory indicate that hypovolemic state induced by acute hemorrhage triggered a heterogeneous and dynamic NOS activation, modulating the cardiovascular response, and the role of NO as a probable messenger that underlines the actions of thyroid hormone at the mitochondrial level is evaluated.
References
•Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
1.6K
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
1.3K
Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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