Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease.
TL;DR: The potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD are focused on.
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TL;DR: Why mitochondria are a potentially important target for drug delivery and how to deliver bioactive molecules selectively to mitochondria within cells are outlined.
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Nitric oxide and the vascular endothelium.
Salvador Moncada,E. A. Higgs +1 more
TL;DR: The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric oxide from L-arginine, which may be an NO-regulated cell signalling system which, under certain circumstances, may lead to the formation of the powerful oxidant species, peroxynitrite, that is associated with a variety of vascular diseases.
425
The regulatory role of nitric oxide in apoptosis.
TL;DR: Recent discoveries in the regulatory role of NO in specific cell types, mechanisms of pro-APoptotic and anti-apoptotic induction by NO, and insights into the effects of NO on tumor biology are reviewed.
403
Localization of Nitric-oxide Synthase in Plant Peroxisomes
Juan B. Barroso,Francisco J. Corpas,Francisco J. Corpas,Alfonso Carreras,Luisa M. Sandalio,Raquel Valderrama,J. M. Palma,José A. Lupiáñez,Luis A. del Río +8 more
TL;DR: The presence of NOS in peroxisomes suggests that these oxidative organelles are a cellular source of nitric oxide (NO) and implies new roles for peroxISomes in the cellular signal transduction mechanisms.
401
References
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Nitric oxide: physiology, pathophysiology, and pharmacology
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
1.6K
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
1.3K
Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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