Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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Citations
Redox control of mitochondrial functions.
TL;DR: Two other aspects of the mitochondrial redox state are discussed: (i) its control of mitochondrial Ca2+ homeostasis, and (ii) the intramitochondrial formation of reactive oxygen or nitrogen species that strongly influence electron flow of the respiratory chain.
32
Inhibitors of Src Family Kinases, Inducible Nitric Oxide Synthase, and NADPH Oxidase as Potential CNS Drug Targets for Neurological Diseases.
TL;DR: In this article, the authors discuss the Src-iNOS-NOX2 signaling pathway and their inhibitors as potential CNS targets for major neurological diseases such as Alzheimer's disease, Parkinson's disease and epilepsy.
31
Recent applications of a synthetic model of cytochrome c oxidase: beyond functional modeling.
James P. Collman,Somdatta Ghosh +1 more
TL;DR: This model has been used to show how H(2)S could induce hibernation by reversibly inhibiting the oxygen binding step involved in respiration and NO is shown to be capable of protecting CcO from toxic inhibitors such as CN(-) and CO.
31
Modulation of brain mitochondrial function by deprenyl.
TL;DR: The results suggest that in vitro effects of deprenyl on mitochondrial function can occur through two different mechanisms, involving nitric oxide synthase inhibition and decreased hydrogen peroxide production.
31
Nitric oxide as a regulator of tissue oxygen consumption
TL;DR: Oxidant stress associated with the production of peroxynitrite from nitric oxide, under conditions such as hypoxia-reoxygenation, convert the reversible inhibition of respiration by Nitric oxide into an irreversible process, which is potentially an important contributor to the expression of alterations in physiological function and tissue injury.
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References
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Nitric oxide: physiology, pathophysiology, and pharmacology
16.5K
The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
1.6K
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
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Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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