Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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TL;DR: Data suggest that NO-induced NMDA receptor activation is closely linked to intramitochondrial NO-peroxynitrite/RNS formation and thereby acts as a major mediator of neuronal cell death.
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Kinetic analysis of thapsigargin-induced thymocyte apoptosis
Juanita Bustamante,Eugenia Di Libero,Mariana Fernandez-Cobo,Nicolás Monti,Enrique Cadenas,Alberto Boveris +5 more
TL;DR: Thapsigargin addition to thymocytes increased cytosolic Ca2+ by a factor of 8.5 and mitochondrial dysfunction followed, and was characterized by decreased respiratory control, membrane depolarization, and decrease cytochrome c content release.
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References
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Nitric oxide: physiology, pathophysiology, and pharmacology
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
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Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
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Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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