Nicotine and Smoking Do Not Decrease Basal Gastric Mucosal Blood Flow in Anesthetized Rats
TL;DR: It is indicated that in the anesthetized rats, hypotension but not intravenous nicotine or cigarette smoke, in the doses given, reduce gastric mucosal blood flow.
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Abstract: The literature regarding the effect of nicotine and cigarette smoke on gastric blood flow is conflicting. The hydrogen gas clearance technique was used to measure the effects of nicotine and cigarette smoke on basal gastric mucosal blood flow in anesthetized rats. Blood flow was measured before, during, and after treatment with either intravenous nicotine (4 or 40 μg/kg/min) or inhaled cigarette smoke (nicotine or nicotine free). Neither intravenous nicotine nor cigarette smoke significantly altered gastric mucosal blood flow. On the other hand, hypotension produced by hemorrhage significantly decreased mucosal blood flow (P<0.05). Thus the technique used could detect a decrease in blood flow. These findings indicate that in the anesthetized rats, hypotension but not intravenous nicotine or cigarette smoke, in the doses given, reduce gastric mucosal blood flow.
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Citations
Gastric mucosal blood flow after smoking in healthy human beings assessed by laser Doppler flowmetry
Tadashi Iwao,Atsushi Toyonaga,Motoki Ikegami,Kazuhiko Oho,Michihiro Sumino,Munenori Sakaki,Hiroyuki Shigemori,Hiroshi Harada,Ei Sasaki,Kyuichi Tanikawa +9 more
TL;DR: It is concluded that cigarette smoking induces a significant reduction in gastric mucosal blood flow and that no heterogeneous response occurs in regional Gastric mucosa, and the laser Doppler flowmeter appears to be a sensitive method to assess rapid change in gastrics mucosa blood flow in human beings.
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TL;DR: The hypothesis that cigarette smoke is indeed harmful to gastric mucosa through defined mechanisms is strengthened through the evidence thus far available.
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An experimental model for studying passive cigarette smoking effects on gastric ulceration
TL;DR: The present experimental model is suitable for studying the adverse interactions between passive smoking and alcohol drinking in gastric ulcer formation in rats and significantly potentiated ethanol-induced gastric mucosal damage.
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The influence of acute or chronic nicotine treatment on ethanol-induced gastric mucosal damage in rats.
TL;DR: It is concluded that acute nicotine pret treatment elevates, whereas chronic nicotine pretreatment differentially affects GMBF, and the acid secretory state of the stomach appears unrelated to the ulcerogenic property of ethanol.
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