NF-κB mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages.
Frank Fang-Yao Lee,Kevin Davidson,Chelsea Harris,Jazalle McClendon,William J. Janssen,Scott Alper +5 more
19
TL;DR: It is concluded that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.
read more
About: This article is published in Journal of Biological Chemistry. The article was published on 01 May 2020. and is currently open access. The article focuses on the topics: Alternative splicing & RNA splicing.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Dietary Genistein Supplementation Alters mRNA Expression Profile and Alternative Splicing Signature in the Thymus of Chicks with Lipopolysaccharide Challenge
TL;DR: In this article, the effect of dietary genistein on thymic transcriptome was investigated in broilers suffering from lipopolysaccharide challenge, and the results showed that dietary GENistein significantly reduced the percentage of CD3+ T lymphocytes by 10.04 % and CD4+/CD8+T lymphocyte ratio by 21.88 %.
7
The effect of lipopolysaccharide extracted from Escherichia coli on total WBCs, granulocytes and on phagocytic activity in female rats
Aziz T. Koro,Adeba Y. Sharif +1 more
TL;DR: The results showed that immunization with the extract of pathogenic strain increases the total leukocytes at a concentration of 90 μg/kg only with a significant increases in phagocytic activity at all concentration, and it also did not cause any significant differences in the granulocytes count.
4
Dietary genistein supplementation alters mRNA expression profile and alternative splicing signature in the thymus of chicks with lipopolysaccharide challenge
01 Feb 2022
TL;DR: In this paper , the effect of dietary genistein on thymic transcriptome was investigated in broilers suffering from lipopolysaccharide challenge, and the results showed that dietary GEN significantly reduced the percentage of CD3+T lymphocytes by 10.04% and CD4+/CD8+ T lymphocyte ratio by 21.88%.
4
RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator.
Frank Fang Yao Lee,Scott Alper +1 more
TL;DR: Two RNA binding proteins, SRSF1 and HNRNPU, are identified that regulate LPS-induced alternative splicing of MyD88, which is thought to act as a negative feedback loop that prevents chronic inflammation.
3
FRTX-02, a selective and potent inhibitor of DYRK1A, modulates inflammatory pathways in mouse models of psoriasis and atopic dermatitis
TL;DR: In this article , dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) has been proposed as a novel regulator of adaptive immune homeostasis through modulating T cell polarization.
3
References
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
10.4K
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
8.3K
The M1 and M2 paradigm of macrophage activation: time for reassessment.
TL;DR: How cytokines and pathogen signals influence macrophages' functional phenotypes and the evidence for M1 and M2 functions is assessed and a paradigm initially based on the role of a restricted set of selected ligands in the immune response is revisited.
Alternative Activation of Macrophages: An Immunologic Functional Perspective
TL;DR: The cellular sources of these cytokines, receptor signaling pathways, and induced markers and gene signatures are reviewed and the concept of macrophage activation in the context of the immune response is revisit.
2.8K