New vaccine production platforms used in developing SARS-CoV-2 vaccine candidates.
70
TL;DR: This review highlights key strategies for generating candidate SARS-CoV-2 vaccines and considerations for vaccine development and clinical trials.
read more
About: This article is published in Vaccine. The article was published on 08 Jan 2021. and is currently open access.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies
Raquel Cid,Jorge Bolivar +1 more
- 21 Jul 2021
TL;DR: The earliest vaccines were developed as live-attenuated or inactivated pathogens, and although they still represent the most extended human vaccine types, they also face some issues, such as the potential to revert to a pathogenic form of liveattenuated formulations or the weaker immune response associated with inactivated vaccines as mentioned in this paper.
95
Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions
Ahmed I. Abulsoud,H. M. El-Husseiny,Ahmed A. El-Husseiny,Hesham A. El-Mahdy,Ahmed Ismail,Samy Y. Elkhawaga,Emad Gamil Khidr,Doaa Fathi,E. A. Mady,Agnieszka Najda,Mohammad Algahtani,Abdulrahman Theyab,Khalaf F. Alsharif,Ashraf Albrakati,Roula Bayram,Mohamed M. Abdel-Daim,Ahmed S. Doghish +16 more
TL;DR: In this paper , a review of SARS-coronavirus-2 pathophysiology and evolution approaches in altered transmission platforms and how they influence the virus characteristics is presented.
82
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges
Kuldeep Dhama,Manish Dhawan,Ruchi Tiwari,Talha Bin Emran,Saikat Mitra,Ali A. Rabaan,Saad Alhumaid,Zainab Al Alawi,Abbas Al Mutair +8 more
TL;DR: The current progress, advantages, prospects, and challenges in developing intranasal COVID-19 vaccines for countering the ongoing pandemic are highlighted.
70
Antibody Responses to Natural SARS-CoV-2 Infection or after COVID-19 Vaccination.
TL;DR: In this paper, a review summarizes the main knowledge that we have about the humoral immune response during the ongoing pandemic of coronavirus disease 2019 (COVID-19) or after vaccination.
66
An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory
Ole Audun Werner Haabeth,Julian J K Lohmeyer,Adrienne Sallets,Timothy R. Blake,Idit Sagiv-Barfi,Debra K. Czerwinski,Blaine G. McCarthy,Abigail E. Powell,Paul A. Wender,Robert M. Waymouth,Ronald Levy +10 more
TL;DR: In this paper, an alternative mRNA vaccine approach using a delivery vehicle called charge-altering releasable transporters (CARTs) has been proposed to tailor the vaccine immunogenicity by inclusion of co-formulated adjuvants such as oligodeoxynucleotides with CpG motifs (CpG-ODN).
52
References
Attenuated Vesicular Stomatitis Viruses as Vaccine Vectors
TL;DR: Two new VSV vectors expressing HA are generated which are completely attenuated for pathogenesis in the mouse model and provide complete protection from lethal influenza virus challenge after intranasal administration.
306
A case for the ancient origin of coronaviruses
Joel O. Wertheim,Daniel K.W. Chu,Joseph S. M. Peiris,Sergei L. Kosakovsky Pond,Leo L.M. Poon +4 more
TL;DR: More realistic evolutionary models are applied and it is found that the time to the most recent ancestor common for all coronaviruses is likely far greater (millions of years) than the previously inferred range.
Fc receptors in antibody‐dependent enhancement of viral infections
Adam Taylor,Suan-Sin Foo,Roberto Bruzzone,Roberto Bruzzone,Luan vu Dinh,Nicholas J. C. King,Suresh Mahalingam +6 more
TL;DR: In vitro studies confirm in vitro studies confirming ADE as a feature of infection for a growing number of viruses and challenges remain in understanding the multilayered molecular mechanisms of ADE and its effect on viral pathogenesis.
251
Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge
Thomas W. Geisbert,Michael Bailey,Lisa E. Hensley,Clement Asiedu,Joan B. Geisbert,Daphne A. Stanley,Anna N. Honko,Joshua C. Johnson,Sabue Mulangu,Maria Grazia Pau,Jerome Custers,Jort Vellinga,Jenny Hendriks,Peter B. Jahrling,Mario Roederer,Jaap Goudsmit,Richard A. Koup,Nancy J. Sullivan +17 more
TL;DR: It is shown that Ad26 and Ad35 vectors generate robust antigen-specific cell-mediated and humoral immune responses against EBOV GP and that Ad5 immune status does not affect the generation of GP-specific immune responses by these vaccines.
237
Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.
James Brett Case,Paul W. Rothlauf,Paul W. Rothlauf,Rita E. Chen,Natasha M. Kafai,Julie M. Fox,Brittany K. Smith,Swathi Shrihari,Broc T. McCune,Ian B. Harvey,Shamus P. Keeler,Louis Marie Bloyet,Haiyan Zhao,Meisheng Ma,Lucas J. Adams,Emma S. Winkler,Michael J. Holtzman,Daved H. Fremont,Sean P. J. Whelan,Michael S. Diamond +19 more
TL;DR: It is shown that vaccination with VSV-eGFP-SARS- CoV-2 generates neutralizing immune responses and protects mice from SARS-CoV- 2.
182
Related Papers (5)
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
Lisa A. Jackson,Evan J. Anderson,Nadine Rouphael,Paul C. Roberts,Mamodikoe Makhene,Rhea N. Coler,Michele Paine McCullough,James D. Chappell,Mark R. Denison,Laura J. Stevens,Andrea J. Pruijssers,Adrian B. McDermott,Britta Flach,Nicole A. Doria-Rose,Kizzmekia S. Corbett,Kaitlyn M. Morabito,Sijy O’Dell,Stephen D. Schmidt,Phillip A. Swanson,Marcelino Padilla,John R. Mascola,Kathleen M. Neuzil,Hamilton Bennett,Wellington Sun,Etza Peters,Mat Makowski,Jim Albert,Kaitlyn Cross,Wendy Buchanan,Rhonda Pikaart-Tautges,Julie E. Ledgerwood,Barney S. Graham,John H. Beigel +32 more
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more