Journal Article10.1016/J.BIOORG.2019.103057
New phenolic Mannich bases with piperazines and their bioactivities.
Halise Inci Gul,Mehtap Tugrak,Mustafa Gul,Sertac Mazlumoglu,Hiroshi Sakagami,İlhami Gülçin,Claudiu T. Supuran +6 more
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TL;DR: In this study, new Mannich bases, 2-(4-hydroxy-3-methoxy-5-((substitutedpiperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1
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About: This article is published in Bioorganic Chemistry. The article was published on 07 Jun 2019. The article focuses on the topics: Piperazine.
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Citations
Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones
Sinan Bilginer,Halise Inci Gul,Feyza Sena Erdal,Hiroshi Sakagami,Serkan Levent,İlhami Gülçin,Claudiu T. Supuran +6 more
TL;DR: Cytotoxicity results pointed out that compound 4, 6-[3-(4-trifluoromethylphenyl)-2-propenoyl]-3H-benzoxazol-2-one, showed the highest cytotoxicity and potency-selectivity expression (PSE) value, and thus can be considered as a lead compound of this study.
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Anticancer Activity of Mannich Bases: A Review of Recent Literature
TL;DR: In this paper , the authors summarized the latest published data on the antiproliferative action and cytotoxic activity of Mannich bases, a structurally heterogeneous category of chemical entities that includes compounds which are synthesized via the grafting of an aminomethyl function onto diverse substrates by means of the Mannich reaction.
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Synthesis, characterization, crystal structure, α‐glycosidase, and acetylcholinesterase inhibitory properties of 1,3‐disubstituted benzimidazolium salts
Selma Bal,Özlem Demirci,Betül Şen,Parham Taslimi,Aydın Aktaş,Yetkin Gök,Muhittin Aygün,İlhami Gülçin +7 more
TL;DR: Chloro-/fluorobenzyl-substituted benzimidazolium salts were synthesized from the reaction of 4-fluoromethane/2-chloro-4-fluorobensyl-sulphamide and chlorinated aromatic hydrocarbons and were characterized using various spectroscopic techniques.
18
Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors
Andrea Angeli,Fabrizio Carta,Alessio Nocentini,Jean-Yves Winum,Raivis Zalubovskis,Valentina Onnis,Wagdy M. Eldehna,Clemente Capasso,Simone Carradori,William A. Donald,Shoukat Dedhar,Claudiu T. Supuran +11 more
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Novel Mannich bases with strong carbonic anhydrases and acetylcholinesterase inhibition effects: 3-(aminomethyl)-6-{3-[4-(trifluoromethyl)phenyl]acryloyl}-2(3H)-benzoxazolones.
TL;DR: In this paper, a new series of Mannich bases, 3-(aminomethyl)-6-{3-[4-(trifluoromethsyl)phenyl]acryloyl}-2( 3H )-benzoxazolones (1a-g ), were synthesized by the Mannich reaction.
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