New Approaches to Cancer Chemotherapy with Methotrexate

TL;DR: Cisplatin nephrotoxicity is clearly dose-related and used to be considered dose limiting; hyperhydration with mannitol-induced saline diuresis may allow administration of high doses and thus circumvent the dose-limiting effect of cisplatin-induced renal toxicity.

TL;DR: An overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy is taken.

TL;DR: The bone marrow is the organ that contains the precursor populations for all major blood components, namely, erythrocytes, leukocytes, and platelets, and it becomes obvious why the latter two are more frequently involved in earlier suppression by chemotherapy.

TL;DR: Author commentary of the process is included to cover anticipation of the patient surge, transport of critical patients, and communication across all agencies--interhospital, local, state, and federal.

TL;DR: 3T3 cells grown in a medium containing a high concentration of serum failed to exhibit either density-dependent inhibition of growth or reduction in the transport of aminoisobutyric acid upon attainment of confluency, suggesting growth regulation apparently exemplified by density- dependent inhibition ofgrowth in vitro seems not to be due to general alterations in membrane permeability and transport.

TL;DR: High doses of methotrexate with citrovorum factor were administered to 10 patients with metastatic osteogenic sarcoma, and a complete regression of pulmonary metastases was obtained and partial regression of tumor persisting in one patient.

TL;DR: Adriamycin has been found effective in metastatic osteogenic sarcoma without detectable metastases, 21 patients were given adjuvant adjamycin therapy two weeks (median) after surgical amputation of the primary lesion.