Neutrophil transendothelial migration: updates and new perspectives

TL;DR: How different microrobots, ranging from tailor-made motile bacteria and tiny bubble-propelled microengines to hybrid spermbots, can be engineered to integrate sophisticated features optimised for precision-targeting of a wide range of cancers are highlighted.

TL;DR: The mechanisms by which neutrophils kill exogenous pathogens are provided before the generation of the oxidizing hypohalous acids HOCl, HOBr and HOSCN during the so-called oxidative burst by the enzyme myeloperoxidase is focused on.

TL;DR: It is suggested that quercetin may be an alternative agent for the treatment of RA by inhibiting neutrophil activities, which are regarded as important therapeutic targets in RA treatment.

TL;DR: The plethora of information on the role of complement receptors will be reviewed, including an analysis of how this functionally and structurally diverse group of molecules acts jointly to exert the full extent of complement regulation of homeostasis.

TL;DR: It is proposed that shear forces exerted on HA-LFA-1 trigger adhesive and invasive filopodia at apical endothelial surfaces and thereby promote lymphocyte crawling and probing for TEM sites.

TL;DR: It is shown that targeting lymphocyte interactions with endothelial basement membrane laminins provides a means of inhibiting disease without compromising innate immune responses, and that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelium basement membrane barrier.

TL;DR: This work proposes that the effect of PI(3)Kγ is through roles in the regulation of some aspects of neutrophil polarization that are relevant to movement, such as integrin-based adhesion and the accumulation of polymerized (F)-actin at the leading-edge.

TL;DR: It is demonstrated that the lipid chemoattractant leukotriene B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendothelial cell migration (rTEM) in vivo.