Journal Article10.1097/NMD.0B013E3181710927
Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 months.
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TL;DR: The results support cognitive safety of Cg25 DBS for TRD, and several areas of cognition that were below average or impaired at baseline improved over follow-up, and these changes were not correlated with improvements in mood.
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Abstract: The purpose of this study was to evaluate preservation of cognitive function after deep brain stimulation (DBS) of the subgenual cingulate (Cg25) for treatment-resistant depression (TRD). We have previously reported on the treatment methods, safety, and 6-month clinical outcome (Mayberg et al., Neuron. 2005;45:651-660). Comprehensive neuropsychological assessments tapping 4 domains of frontal lobe function, and general cognitive abilities, were completed before implantation and at 3, 6, and 12 months postonset of continuous DBS in 6 TRD patients. No adverse neuropsychological effects were noted following surgery, onset and maintenance of DBS with the exception of transient motor slowing noted at 3 and 6 months that improved to normative levels by 12 months. Several areas of cognition that were below average or impaired at baseline improved over follow-up, and these changes were not correlated with improvements in mood. Though the sample size is small, these results support cognitive safety of Cg25 DBS for TRD.
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Citations
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Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression.
Andres M. Lozano,Helen S. Mayberg,Helen S. Mayberg,Peter Giacobbe,Clement Hamani,R. Cameron Craddock,Sydney H. Kennedy +6 more
TL;DR: This study suggests that DBS is relatively safe and provides significant improvement in patients with TRD and likely acts by modulating brain networks whose dysfunction leads to depression.
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Cognitive Mechanisms of Treatment in Depression
TL;DR: A ‘cognitive neuropsychological’ model of depression is proposed, suggesting that negative information processing biases have a central causal role in the development of symptoms of depression, and that treatments exert their beneficial effects by abolishing these biases.
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The Subcallosal Cingulate Gyrus in the Context of Major Depression
Clement Hamani,Clement Hamani,Helen S. Mayberg,Scellig S D Stone,Adrian W. Laxton,Suzanne N. Haber,Andres M. Lozano +6 more
TL;DR: The anatomic and histologic attributes of the SCG and the morphologic and imaging changes observed in depression are reviewed and particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region.
481
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Deep brain stimulation for treatment-resistant depression.
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