Neuroprotective Therapy for Stroke and Ischemic Disease
Paul A. Lapchak,John H. Zhang +1 more
- 01 Jan 2017
50
TL;DR: The Springer Series in Translational Stroke Research will cover basic, translational and clinical research, emphasizing novel approaches to help translate scientific discoveries from basic stroke research into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma.
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Abstract: Submission information at the series homepage and springer.com/authors Order online at springer.com ▶ or for the Americas call (toll free) 1-800-SPRINGER ▶ or email us at: customerservice@springer.com. ▶ For outside the Americas call +49 (0) 6221-345-4301 ▶ or email us at: customerservice@springer.com. Springer Series in Translational Stroke Research Series Ed.: J. Zhang The Springer Series in Translational Stroke Research will cover basic, translational and clinical research, emphasizing novel approaches to help translate scientific discoveries from basic stroke research into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma.
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Citations
Synaptic scaffold protein PSD-95: a therapeutic target for Alzheimer’s disease
Xing Fan,Hao Wang,Ming-Zhe Li,Jianlan Gu,Wei Qian +4 more
Abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disorder marked by gradual cognitive deterioration and distinct neuropathological characteristics. The abnormal accumulation of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) are the hallmarks of AD. In fact, synaptic loss and damage occur earlier than amyloid plaques and NFTs in the progression of AD and are most closely associated with the cognitive deficits exhibited by AD patients. In this review, we discuss the expression level, localization, posttranslational modification and interaction proteins of PSD-95, as well as their roles in synaptic plastisity. We also review the mechanisms through which PSD-95 contributes to synaptic dysfunction in AD. Moreover, the potential of PSD-95 as an early biomarker for AD is also discussed, along with the therapeutic approaches that target PSD-95 for patients afflicted with the disease. The objective of this review is to offer comprehensive insights into the early pathogenesis of Alzheimer's disease and to aid in the development of novel diagnostic and treatment methodologies grounded in this understanding.
Neuroimaging-Guided Transcranial Magnetic and Direct Current Stimulation in MCI: Toward an Individual, Effective and Disease-Modifying Treatment.
TL;DR: In this article, the authors reviewed the combinatory approach of noninvasive brain stimulation (NIBS) with various neuroimaging and electrophysiological methods and found that NIBS is an attractive treatment option in the early phases of neurodegenerative diseases, such as MCI, with its beneficial modifying effects on cellular neuroplasticity.
Behavioral assessment of post-stroke depression and anxiety in rodents
Danyang Chen,Junmin Wang,Yinpei Xing,Peijun Jia,Yuheng Zhang,Jiarui Wang,Honglei Ren,Anh Le,Xuemei Chen,Jian Wang +9 more
- 01 Jun 2020
TL;DR: A review of behavioral protocols used to assess post-stroke depression and anxiety in rodent models to facilitate the performance of behavioral tests in basic research and provide references for the clinical diagnosis and treatment of post- stroke depression.
The Hippocratic Doctrine of "the Acute Brain Suffering" as the Brain Stroke.
TL;DR: Both therapeutic approach and symptomatology exhibited significant similarities with the modern concept of the stroke in modern clinical practice.
Excitatory and inhibitory amino acid neurotransmitters in stroke: from neurotoxicity to ischemic tolerance
Diana Amantea,Giacinto Bagetta +1 more
TL;DR: Blocking receptor stimulation through glutamate grabbing, inhibiting downstream transduction pathways or selectively antagonizing detrimental NMDA receptor subpopulations represent promising strategies to rescue ischemic brain injury with limited side effects.