Neuroprotective effect of berberine chloride on cognitive impairment and hippocampal damage in experimental model of vascular dementia.
Mahila Lotfi Aski,Mohammad Ebrahim Rezvani,Mehdi Khaksari,Zeynab Hafizi,Zeynab Pirmoradi,Somayeh Niknazar,Fatemeh Zare Mehrjerdi +6 more
TL;DR: Berberine chloride may be considered as a potential treatment for cognitive deficits and neuronal injury caused by CCH in the hippocampal CA1 area, which caused cognitive impairment and neuronal damages within CA1 hippocampal subregion.
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Abstract: Objective(s):The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: To induce vascular dementia, chronic bilateral common carotid artery occlusion was performed on male Wistar rats. After surgery, the rats were treated daily by oral administration of berberine chloride (50 mg/kg) for two months. The cognition function of treated rats, were evaluated by Morris Water Maze (MWM) test. In addition, Nissl and TUNEL staining were chosen to assess neuronal damage within the hippocampal CA1 area. Results: It was obvious that chronic cerebral hypoperfusion (CCH), caused cognitive impairment and neuronal damages within CA1 hippocampal subregion. Berberine chloride was able to prevent cognitive deficits, (P<0.05) and reversed CCH-induced hippocampal neuronal loss and apoptosis, (P<0.05). Conclusion: Berberine chloride may be considered as a potential treatment for cognitive deficits and neuronal injury caused by CCH in the hippocampal CA1 area.
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Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats.
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TL;DR: In this article, the potential neuroprotective effect of BBR in DOX-induced neurodegeneration and cognitive deficits was evaluated, where the authors showed that BBR significantly attenuated behavioral defects in doxorubicin-induced cognitive impairment and reversed histopathological abnormalities.
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MicroRNA-210-5p Contributes to Cognitive Impairment in Early Vascular Dementia Rat Model Through Targeting Snap25.
Zhenxing Ren,Junlong Yu,Zimei Wu,Wenwen Si,Xianqian Li,Yuqing Liu,Jianhong Zhou,Rudong Deng,Dongfeng Chen +8 more
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Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.
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References
Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases.
TL;DR: Thorough characterization of the model suggests that 2VO in the rat is suitable for the development of potentially neuroprotective strategies in neurodegenerative diseases.
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Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes
Pravinkumar Bhutada,Yogita Mundhada,Kuldeep Bansod,Santosh Tawari,Shaktipal Patil,Pankaj Dixit,Sudhir N. Umathe,Dharmendra Mundhada +7 more
TL;DR: It is demonstrated treatment with berberine prevents the changes in oxidative stress and ChE activity, and consequently memory impairment in diabetic rats.
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Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat.
Hidekazu Tomimoto,Masafumi Ihara,Hideaki Wakita,Ryo Ohtani,Jin Xi Lin,Ichiro Akiguchi,Makoto Kinoshita,Hiroshi Shibasaki +7 more
TL;DR: It is indicated that chronic cerebral hypoperfusion induces white matter degeneration in association with DNA fragmentation in oligodendroglia, and molecules involved in apoptotic signaling such as TNF-α and Bax were up-regulated in glial cells.
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Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.
Robert Domitrović,Olga Cvijanović,Ester Pernjak-Pugel,Marko Škoda,Lorena Mikelić,Zeljka Crncevic-Orlic +5 more
TL;DR: The results showed the nephroprotective activity of berberine against CP-induced renal injury, which could be attributed to the inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.
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Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells.
Sangmin Kim,Jae Hyuck Choi,Jong Bin Kim,Seok Jin Nam,Jung-Hyun Yang,Jung-Han Kim,Jeong Eon Lee +6 more
TL;DR: It is suggested that TNF-α-induced MMP-9 expression and cell invasion are decreased by BBR through the suppression of AP-1 DNA binding activity in MDA-MB-231 human breast cancer cells.
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