Journal Article10.1146/ANNUREV.NEURO.27.070203.144259
Neuronal substrates of complex behaviors in C. elegans
Mario de Bono,Andres V. Maricq +1 more
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TL;DR: This work has identified gene products required for nervous system function and elucidated the molecular and neural bases of behaviors in the nematode Caenorhabditis elegans.
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Abstract: A current challenge in neuroscience is to bridge the gaps between genes, proteins, neurons, neural circuits, and behavior in a single animal model. The nematode Caenorhabditis elegans has unique features that facilitate this synthesis. Its nervous system includes exactly 302 neurons, and their pattern of synaptic connectivity is known. With only five olfactory neurons, C. elegans can dynamically respond to dozens of attractive and repellant odors. Thermosensory neurons enable the nematode to remember its cultivation temperature and to track narrow isotherms. Polymodal sensory neurons detect a wide range of nociceptive cues and signal robust escape responses. Pairing of sensory stimuli leads to long-lived changes in behavior consistent with associative learning. Worms exhibit social behaviors and complex ultradian rhythms driven by Ca2+ oscillators with clock-like properties. Genetic analysis has identified gene products required for nervous system function and elucidated the molecular and neural bases of ...
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Citations
Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans
Sreekanth H. Chalasani,Nikos Chronis,Makoto Tsunozaki,Jesse M. Gray,Daniel Ramot,Miriam B. Goodman,Cornelia I. Bargmann +6 more
TL;DR: Information processing by Caenorhabditis elegans olfactory neurons and interneurons resembles information flow from vertebrate photoreceptors to ‘OFF” bipolar and ‘ON’ bipolar neurons, indicating a conserved or convergent strategy for sensory information processing.
Dimensionality and Dynamics in the Behavior of C. elegans
TL;DR: It is shown that the space of shapes adopted by the nematode Caenorhabditis elegans is low dimensional, with just four dimensions accounting for 95% of the shape variance, and Stimulus-dependent correlations among the different modes suggest that one can generate more reliable behaviors by synchronizing stimuli to the state of the worm in shape space.
A framework for studying emotions across species.
David J. Anderson,Ralph Adolphs +1 more
TL;DR: It is argued that emotional behaviors are a class of behaviors that express internal emotion states that exhibit certain general functional and adaptive properties that apply across any specific human emotions like fear or anger, as well as across phylogeny.
597
Neural Network Dynamics
TL;DR: This work reviews network models of internally generated activity, focusing on three types of network dynamics: sustained responses to transient stimuli, which provide a model of working memory; oscillatory network activity; and chaotic activity, which models complex patterns of background spiking in cortical and other circuits.
Beyond the connectome: how neuromodulators shape neural circuits.
TL;DR: Wiring diagrams of defined neural circuits in crustaceans, C. elegans, Drosophila, and the vertebrate retina reveal the ability of modulators and sensory context to reconfigure information processing by changing the composition and activity of functional circuits.
551
References
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
Jesse M. Gray,David S. Karow,Hang Lu,Andy J. Chang,Jennifer S. Chang,Ronald E. Ellis,Michael A. Marletta,Michael A. Marletta,Cornelia I. Bargmann +8 more
TL;DR: It is shown that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5–12% oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments.
OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans.
TL;DR: Osm-9 as mentioned in this paper encoded a protein with ankyrin repeats and multiple predicted transmembrane domains that has limited similarity to the Drosophila phototransduction channels transient receptor potential (TRP) and TRP-like (TRPL).
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Neural regulation of thermotaxis in Caenorhabditis elegans
Ikue Mori,Yasumi Ohshima +1 more
TL;DR: A neural model is proposed in which regulation of the activities of the two interneurons in opposite directions, depending on the cultivation temperature, is essential for thermotaxis, and an amphid sensory neuron, AFD, is a major thermosensory neuron.
639
Serotonin and octopamine in the nematode Caenorhabditis elegans
TL;DR: Exogenous serotonin and octopamine elicit specific and opposite behavioral responses in Caenorhabditis elegans, suggesting that these compounds function physiologically as antagonists.
626
The Caenorhabditis elegans male: postembryonic development of nongonadal structures.
TL;DR: The nongonadal cells in the male nematode Caenorhabditis elegans have been followed through maturation by Nomarski microscopy and this region has been reconstructed by serial section electron microscopy in order to identify the cell types that arise from known lineages.
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