Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells

TL;DR: It is demonstrated that, in the absence of synaptic excitation, the basic-helix-loop- Helix (bHLH)-PAS family transcription factor ARNT2 recruits the NCoR2 co-repressor complex to suppress neuronal activity-dependent regulatory elements and maintain low basal levels of inducible genes.

TL;DR: The PAS domain is a ubiquitous sensor domain that originated in bacteria and was horizontally transferred to archaea and eukaryotes. It has a diverse range of functions including gas sensing, redox sensing, and light sensing.

TL;DR: In this paper, the role of the vasculature in pancreatic β-cell regeneration was investigated by cross-crossing a zebrafish βcell ablation model into the avascular npas4l mutant (i.e., cloche).

TL;DR: In this paper , a large-scale, multi-condition, single-cell dataset was constructed from human islets exposed to conditions that would acutely induce or inhibit intracellular Ca2+ signalling, while preserving biological heterogeneity.

TL;DR: The mT/mG mouse as mentioned in this paper is a double-fluorescent Cre reporter mouse that expresses membrane-targeted tandem dimer tomato (mT) prior to Cre-mediated excision and membranetargeted green fluorescent protein (mG) after excision.

TL;DR: In this paper, the authors tested whether mitochondria act as O2 sensors during hypoxia and whether cobalt activated transcription by increasing the generation of reactive oxygen species (ROS).

TL;DR: Findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1α stabilization during hypoxia and that catalase abolishes hypoxic response element-luciferase expression during Hypoxia.

TL;DR: New data suggests that this metabolic switch within the solid tumour may provide a benefit to the tumour not by increasing glycolysis but by decreasing mitochondrial activity.