Neurofilament relates to white matter microstructure in older adults
Elizabeth E. Moore,Timothy J. Hohman,Faizan Badami,Kimberly R. Pechman,Katie E. Osborn,Lealani Mae Y. Acosta,Susan P. Bell,Michelle A Babicz,Katherine A. Gifford,Adam W. Anderson,Lee E. Goldstein,Kaj Blennow,Henrik Zetterberg,Angela L. Jefferson +13 more
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TL;DR: Results highlight the role of elevated NFL in predicting WM damage in cognitively impaired older adults who are amyloid-negative, tau-positive, or meet suspected nonamyloid pathology criteria and suggest increased NFL, a biomarker of axonal injury, is correlated with compromised WM microstructure.
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About: This article is published in Neurobiology of Aging. The article was published on 28 Jun 2018. and is currently open access. The article focuses on the topics: White matter.
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Citations
Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease
Jue Wang,Kexin Wang,Tiantian Liu,Liang Wang,Dingjie Suo,Yunyan Xie,Shintaro Funahashi,Jinglong Wu,Guangying Pei +8 more
TL;DR: In this paper , the authors used sliding windows, Pearson correlation, and clustering analysis to investigate the different levels of information transformation states of subjects with and patients with Alzheimer's disease.
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The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,C. R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +17 more
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TL;DR: A conceptual framework and operational research criteria are proposed, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies and it is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD.
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Stephen M. Smith,Mark Jenkinson,Heidi Johansen-Berg,Daniel Rueckert,Thomas E. Nichols,Clare E. Mackay,Kate E. Watkins,Olga Ciccarelli,M Z Cader,Paul M. Matthews,Timothy E.J. Behrens +10 more
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The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease
Marilyn S. Albert,Steven T. DeKosky,Dennis W. Dickson,Bruno Dubois,Howard Feldman,Nick C. Fox,Anthony Gamst,David M. Holtzman,William J. Jagust,Ronald C. Petersen,Peter J. Snyder,Maria C. Carrillo,Bill Thies,Creighton H. Phelps +13 more
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TL;DR: Criteria for the symptomatic predementia phase of Alzheimer’s disease (AD), referred to in this article as mild cognitive impairment due to AD, has four levels of certainty, depending on the presence and nature of the biomarker findings.
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