Neurodegeneration in zebrafish embryos and adults after cadmium exposure.
TL;DR: Evidence is indicative that cadmium, even at a sub-lethal concentration, induces cell death in the brain of embryos but also in adults of zebrafish in which the phenomenon appears time-dependent.
read more
Abstract: Cadmium is a biologically non-essential metal. It is also toxic to many organs including the brain. The aim of this study was to analyse the neurodegenerative effects of this metal in embryos and adults of zebrafish exposed to sub-lethal concentrations of cadmium. The study was performed by cytochemical stainings. Six hours after fertilisation (hpf) zebrafish embryos were treated for 24 hours with 9 I¼M of cadmium and subsequently stained with Acridine orange in whole mount to detect apoptosis in the brain. Adult zebrafish were treated for 16 days with the same concentration of cadmium, and cell death in the brain was detected by Fluoro-Jade B staining at 2, 7 and 16 days of treatment. An increase in cell death was observed only at 16 days of treatment in adults, while an increase in apoptotic events was revealed in the brain of embryos after 24 h of treatment. This evidence is indicative that cadmium, even at a sub-lethal concentration, induces cell death in the brain of embryos but also in adults of zebrafish in which the phenomenon appears time-dependent.Â.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Environmental pollution and toxic substances: Cellular apoptosis as a key parameter in a sensible model like fish.
Hossein Anvarifar,Abdolsamad Keramat Amirkolaie,Ali M. Jalali,Hamed Kolangi Miandare,Alaa El-Din H. Sayed,Sema İşisağ Üçüncü,Hossein Ouraji,Marcello Ceci,Nicla Romano +8 more
TL;DR: A review of the current knowledge on the interactions of environmental chemicals and programmed cell death in fish species found that this review could be useful tool to study the cytotoxic/apoptotic effects of different pollutants inFish species.
97
The Effect of Oxidative Stress-Induced Autophagy by Cadmium Exposure in Kidney, Liver, and Bone Damage, and Neurotoxicity
Yong-Xin Ma,Qunchao Su,Chengguang Yue,Hui Zou,Jiaqiao Zhu,Hongyan Zhao,Ruilong Song,Zongping Liu +7 more
TL;DR: A detailed review of the current literature on autophagy in cadmium-induced tissue damage can be found in this article , where the authors provided a detailed survey of the existing literature.
Effects of aluminium and cadmium on hatching and swimming ability in developing zebrafish.
TL;DR: Data show that cadmium and aluminium can delay hatching and alter swimming ability in the early developmental stages of zebrafish, albeit with different effects, suggesting that exposure to sublethal concentrations of both metals can change behavioural parameters.
77
The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease.
TL;DR: Zebrafish is an ideal model for the study of regeneration, reorganization and repair mechanisms following olfactory toxicant exposure, and the anatomical, morphological, and functional organization of the Olfactory system of zebrafish are focused on.
68
Effects of four food dyes on development of three model species, Cucumis sativus, Artemia salina and Danio rerio: Assessment of potential risk for the environment
Chiara Maria Motta,Palma Simoniello,Carmen Arena,Teresa Capriello,Raffaele Panzuto,Ermenegilda Vitale,Claudio Agnisola,Monica Tizzano,Bice Avallone,Ida Ferrandino +9 more
TL;DR: The results demonstrated that the food dyes examined are far from being safe for the aquatic organisms as well as land organisms exposed during watering with contaminated water.
47
References
Apoptosis: A Review of Programmed Cell Death
TL;DR: The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptoses in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptotic proteins.
Apoptosis in neurodegenerative disorders
TL;DR: With the identification of mechanisms that either promote or prevent neuronal apoptosis come new approaches for preventing and treating neurodegenerative disorders.
1.6K
The Role of Oxidative Stress in Parkinson’s Disease
TL;DR: Animal models of PD have yielded some insights into the molecular pathways of neuronal degeneration and highlighted previously unknown mechanisms by which oxidative stress contributes to PD, but therapeutic attempts to target the general state of oxidative stress in clinical trials have failed to demonstrate an impact on disease progression.
Cellular Stress Responses: Cell Survival and Cell Death
TL;DR: The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.