Journal Article10.1037//0894-4105.12.3.426
Neurocognitive Deficit in Schizophrenia: A Quantitative Review of the Evidence
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TL;DR: The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
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Abstract: The neurocognitive literature on test performance in schizophrenia is reviewed quantitatively. The authors report 22 mean effect sizes from 204 studies to index schizophrenia versus control differences in global and selective verbal memory, nonverbal memory, bilateral and unilateral motor performance, visual and auditory attention, general intelligence, spatial ability, executive function, language, and interhemispheric tactile-transfer test performance. Moderate to large raw effect sizes (d > .60) were obtained for all 22 neurocognitive test variables, and none of the associated confidence intervals included zero. The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
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Citations
Going up in Smoke? A Review of nAChRs-based Treatment Strategies for Improving Cognition in Schizophrenia
TL;DR: Clinical evidence of nAChRs dysfunction in schizophrenia is summarized, clinical studies testing either nicotine or nicotinic medications for the treatment of cognitive impairment in schizophrenia are reviewed and some evidence suggests beneficial effects of n AChRs based treatments for the attentional deficits associated with schizophrenia.
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Pamela DeRosse,Pamela DeRosse,Toshikazu Ikuta,Bart D. Peters,Bart D. Peters,Katherine H. Karlsgodt,Katherine H. Karlsgodt,Philip R. Szeszko,Anil K. Malhotra +8 more
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Psychotic symptoms, cognition and affect as predictors of psychosocial problems and functional change in first-episode psychosis
TL;DR: In this article, the authors investigated how psychopathology and cognitive deficits are associated with psychosocial problems at baseline, and how these predict psycho-social functioning at 12-months follow-up.
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Sustaining attention to simple visual tasks: a central deficit in schizophrenia? A systematic review
TL;DR: Two types of assessment lead to opposite findings; they do not evaluate sustained attention the same way; therefore, further research is needed to investigate the underlying cognitive control mechanisms of changes in sustained attention in schizophrenia.
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The Key Role of Emotions in the Schizophrenia Puzzle
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