Journal Article10.1037//0894-4105.12.3.426
Neurocognitive Deficit in Schizophrenia: A Quantitative Review of the Evidence
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TL;DR: The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
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Abstract: The neurocognitive literature on test performance in schizophrenia is reviewed quantitatively. The authors report 22 mean effect sizes from 204 studies to index schizophrenia versus control differences in global and selective verbal memory, nonverbal memory, bilateral and unilateral motor performance, visual and auditory attention, general intelligence, spatial ability, executive function, language, and interhemispheric tactile-transfer test performance. Moderate to large raw effect sizes (d > .60) were obtained for all 22 neurocognitive test variables, and none of the associated confidence intervals included zero. The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests.
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Citations
Using Neuroplasticity-Based Auditory Training to Improve Verbal Memory in Schizophrenia
TL;DR: Intensive training in early auditory processes and auditory-verbal learning results in substantial gains in verbal cognitive processes relevant to psychosocial functioning in schizophrenia, due to a training method that addresses the early perceptual impairments in the illness.
Strange Feelings: Do Amygdala Abnormalities Dysregulate the Emotional Brain in Schizophrenia?
André Aleman,René S. Kahn +1 more
TL;DR: It is demonstrated that dysfunction of the emotional brain is a hallmark of schizophrenia, and a model that integrates previous neural accounts of emotional abnormalities in schizophrenia is proposed, and specifies a neural basis for differential emotional correlates of positive and negative symptoms is proposed.
386
Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.
TL;DR: The literature on cognitive deficits across the life span of individuals with psychotic disorder and psychotic-like experiences is reviewed, highlighting the dimensional nature of both psychosis and cognitive ability and identifying premorbid generalized cognitive impairment in schizophrenia that worsens throughout development and stabilizes by the first-episode of psychosis, suggesting a neurodevelopmental course.
Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms.
TL;DR: It is concluded that verbal declarative memory is significantly impaired in schizophrenia and is largely accounted for by deficits in the encoding stage, and components of the deficit are associated with a genetic vulnerability to the illness, and are independent of the frank psychotic illness.
371
The Primacy of Cognition in Schizophrenia.
TL;DR: Cognitive tasks and concepts are used increasingly in schizophrenia science and treatment and chronic stress, genes, brain disturbances, task structure, gender, and sociocultural background may all enhance the sensitivity of cognitive performance to schizophrenia.
359
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