Neural substrates of human fear generalization: A 7T-fMRI investigation.
Ashley A. Huggins,Carissa N. Weis,Elizabeth A. Parisi,Kenneth P. Bennett,Vladimir Miskovic,Christine L. Larson +5 more
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TL;DR: In this paper, the authors utilized the high spatial resolution of 7T fMRI to characterize the neural circuits involved in threat discrimination and generalization, and examined potential modulating effects of trait anxiety and intolerance of uncertainty on neural activation during threat generalization.
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About: This article is published in NeuroImage. The article was published on 01 Oct 2021. and is currently open access. The article focuses on the topics: Generalization (learning) & Ventromedial prefrontal cortex.
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Citations
A meta-analysis of conditioned fear generalization in anxiety-related disorders
Samuel E. Cooper,Eva A.M. van Dis,Muriel A. Hagenaars,Angelos-Miltiadis Krypotos,Charles B. Nemeroff,Shmuel Lissek,Iris M. Engelhard,Joseph E. Dunsmoor +7 more
TL;DR: In this paper , the authors conducted a meta-analysis of studies reporting behavioral measures (subjective ratings and psychophysiological indices) of fear generalization in anxiety-related disorder vs. comparison groups.
Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action
TL;DR: Light is shed on agomelatine’s mechanism of action in treating GAD, which exerts its anxiolytic actions by mechanisms clearly distinct from those of other agents currently employed for the management of GAD.
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Effects of RU486 in Treatment of Traumatic Stress-Induced Glucocorticoid Dysregulation and Fear-Related Abnormalities: Early versus Late Intervention
TL;DR: Early RU486 administration could inhibit SPS-induced behavioral abnormalities and glucocorticoid system dysregulation by reversing the Sps-induced fear extinction deficit, and preventing SPS
Threat vigilance and intrinsic amygdala connectivity
TL;DR: It is suggested that this subcortical circuitry may be chronically engaged in hypervigilant individuals, but that amygdala‐prefrontal circuitry may only be engaged in response to anxiogenic stimuli.
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Sometimes I feel the fear of uncertainty: How intolerance of uncertainty and trait anxiety impact fear acquisition, extinction and the return of fear.
Adrian Wroblewski,Maike Hollandt,Yunbo Yang,Isabelle C. Ridderbusch,Anne Pietzner,Christoph Szeska,Martin Lotze,Hans-Ulrich Wittchen,Ingmar Heinig,Andre Pittig,Volker Arolt,Katja Koelkebeck,Constantin A. Rothkopf,Dirk Adolph,Jürgen Margraf,Ulrike Lueken,Paul Pauli,Martin J. Herrmann,Markus H. Winkler,Andreas Ströhle,Udo Dannlowski,Tilo Kircher,Alfons O. Hamm,Benjamin Straube,Jan Richter +24 more
TL;DR: In this paper , the authors compared two groups with high vs. low trait anxiety during periods of low (instructed fear acquisition) and high levels of uncertainty (delayed non-instructed extinction training and reinstatement).
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