Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

TL;DR: In this paper , the authors focus on five major metabolic pathways including glycolysis, pentose phosphate pathway, fatty acid oxidation and synthesis, tricarboxylic acid cycle and amino acid metabolism and discuss how they sustain and regulate macrophage immune function in response to parasitic, bacterial and viral infections as well as trained immunity.

TL;DR: This review discusses macrophages in peripheral nerve injury and how Schwann cells may regulate their behavior, particularly the Schwann cell, the glial cell of the peripheral nervous system.

TL;DR: Citrate-derived itaconate acts as a negative regulator of inflammation by modulating the synthesis of the inflammatory mediators and results in reduction of NO, ROS and PGE2 levels suggesting that the citrate pathway can be a new target to be addressed in inflammation.

TL;DR: In this article, the effects of physiological and pathophysiological hypoxia on innate and adaptive immune activity are summarized and an overview on the control of immune response by cellular hypoxias-induced pathways with focus on the role of HIFs and discuss the opportunity to target hypoxiosis-sensitive pathways for the treatment of cancer and autoimmunity.

TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.

TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.

TL;DR: KEGG Mapper, a collection of tools for KEGG PATHWAY, BRITE and MODULE mapping, enabling integration and interpretation of large-scale data sets and recent enhancements to the K EGG content, especially the incorporation of disease and drug information used in practice and in society, to support translational bioinformatics.

TL;DR: The four stages of orderly inflammation mediated by macrophages are discussed: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis.