Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

TL;DR: In this paper, the authors provide an overview on TLR signaling and their current understanding of TLR agonists which show promise as immunotherapeutic agents for combating infection, and a brief discussion on the underlying mechanisms is also provided.

TL;DR: It was found that bacterial and fungal infections produced similar effects on macrophage functional differentiation, and Alteration of glycolytic pathway activation was required for the functional differentiation of pro-inflammatory macrophages in protecting against bacterial andfungal infections.

TL;DR: In this article, the role of monocyte and macrophage dynamics in atherosclerotic disease and identify gaps in knowledge that they hope will allow for advancing therapeutic treatment or prevention strategies for cardiovascular disease.

TL;DR: The present contribution reviews the evidence that links intracellular and extracellular NAMPT to myeloid biology, for example governing monocyte/macrophage differentiation, polarization and migration and the data showing that inhibition of the enzymatic activity or the neutralization of the cytokine is beneficial in preclinical animal models.

TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.

TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.

TL;DR: KEGG Mapper, a collection of tools for KEGG PATHWAY, BRITE and MODULE mapping, enabling integration and interpretation of large-scale data sets and recent enhancements to the K EGG content, especially the incorporation of disease and drug information used in practice and in society, to support translational bioinformatics.

TL;DR: The four stages of orderly inflammation mediated by macrophages are discussed: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis.