Journal Article10.1093/postmj/qgaf080
Netrin-1: pioneering new Frontiers in peripheral nerve injury treatment
Chun Qin,Song Zhang,Guo Hua,Lingtong Kong,Jiaming Cao,Xin Tan,Shuogui Xu +6 more
Abstract: Abstract Background The incidence of peripheral nerve injury has increased annually and it has become a common traumatic disease in clinical practice. Methods Netrin-1 is a crucial extracellular matrix protein that plays a significant role in nerve development and regeneration, and is involved in the construction of a local neurological injury regional regeneration and repair microenvironment to support axon and myelin repair growth. Results Recent studies have highlighted its important roles in the repair of peripheral nerve injuries. Conclusion This review clarifies how Netrin-1 in fluences neuronal survival, promotes axonal regeneration, and modulates neuro-inflammation.
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References
Aligned Graphene Mesh-Supported Double Network Natural Hydrogel Conduit Loaded with Netrin-1 for Peripheral Nerve Regeneration
Qun Huang,Yuting Cai,Yuting Cai,Xing Zhang,Junchao Liu,Zhenjing Liu,Bo Li,Hoilun Wong,Feng Xu,Liyuan Sheng,Dazhi Sun,Jinbao Qin,Zhengtang Luo,Xinwu Lu +13 more
TL;DR: In this article, a graphene mesh-supported double-network (DN) hydrogel scaffold, loaded with netrin-1, was used to promote the regeneration of peripheral nerve and the restoration of denervated muscle.
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Netrin-1: An emerging player in inflammatory diseases.
TL;DR: In this article , the authors reviewed recent advances in the understanding of netrin-1 and its receptors in many inflammatory diseases and look forward to the bioavailability of net-1 for the future.
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Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability
TL;DR: In this paper , an axonal guidance molecule, Netrin-1 (NTN-1), has been reported to have strong inflammatory regulatory and neuroprotective effects in postoperative delirium.
Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral Nerve after Injury
Jeremy Tsung-Chieh Chen,Lea Schmidt,Christina Schürger,Mohammed K Hankir,Susanne M. Krug,Heike L. Rittner +5 more
TL;DR: In this paper, the role of the endothelial and myelin barrier in pain processing after nerve damage and reveal that exogenous netrin-1 restores their function to mitigate CCI-induced hypersensitivity via Neo1.
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