Journal Article10.1016/0021-9150(92)90191-I
Neopterin levels in patients with coronary artery disease.
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About: This article is published in Atherosclerosis. The article was published on 01 May 1992. The article focuses on the topics: Coronary artery disease & Neopterin.
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Citations
Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries
Michael Erren,Holger Reinecke,Ralf Junker,Manfred Fobker,Helmut Schulte,Josef O. Schurek,Jürgen Kropf,Sebastian Kerber,Günter Breithardt,Gerd Assmann,Paul Cullen +10 more
TL;DR: Increased plasma levels of CRP, SAA, IL-6, TGF-beta, neopterin, and procalcitonin constitute an inflammatory signature of advanced atherosclerosis and are correlated with the extent of disease but do not provide discriminatory diagnostic power over and above established risk factors.
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Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris
TL;DR: Serum neopterin is an independent predictor of major adverse coronary events in patients with chronic stable angina pectoris, and this marker of macrophage activation may be useful for risk stratification in Patients with chronicstable angina.
Increased concentrations of neopterin in carotid atherosclerosis
Günter Weiss,Johann Willeit,Stefan Kiechl,Dietmar Fuchs,Elmar Jarosch,Friedrich Oberhollenzer,Gilbert Reibnegger,Gernot P. Tilz,Franz Gerstenbrand,Helmut Wachter +9 more
TL;DR: The data show that the macrophage-derived immune activation marker neopterin is closely correlated with the extent of carotid atherosclerosis, and chronic activation of immune cells, preferentially of macrophages, may play a key role in atherogenesis and/or progression of Atherosclerosis.
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The role of neopterin in atherogenesis and cardiovascular risk assessment.
Dietmar Fuchs,Pablo Avanzas,Ramón Arroyo-Espliguero,Marcel Jenny,Luciano Consuegra-Sánchez,Juan Carlos Kaski +5 more
TL;DR: Current data suggest that the diagnostic performance of neopterin testing is comparable to that of well established biomarkers such as C-reactive protein and cholesterol plasma levels.
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Increased Neopterin in Patients With Chronic and Acute Coronary Syndromes
Martin Schumacher,G. Halwachs,Franz Tatzber,Friedrich Fruhwald,Robert Zweiker,N. Watzinger,Bernd Eber,Martie Wilders-Truschnig,Hermann Esterbauer,Werner Klein +9 more
TL;DR: The hypothesis of an activation of monocytes and macrophages in patients with an acute or chronic coronary syndrome is supported, as neopterin as a marker for macrophage activation is significantly increased in Patients with chronic CAD and more pronounced in patientswith AMI shortly after the onset of symptoms.
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References
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.
Ch. Huber,J R Batchelor,Dietmar Fuchs,Arno Hausen,A. Lang,Dietger Niederwieser,Gilbert Reibnegger,P. Swetly,Jakob Troppmair,H. Wachter +9 more
TL;DR: It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
Elevated serum neopterin levels in atherosclerosis
Franz Tatzber,Hans Rabl,Karl Koriska,Ulrike Erhart,Herbert Puhl,Georg Waeg,Angelika Krebs,Hermann Esterbauer +7 more
TL;DR: Data indicate that neopterin plasma levels might be a valuable parameter in activity staging and therapeutic follow up of atherosclerotic patients and an involvement of the nonspecific immune system in atherogenesis is suggested by the increased plasma neopterIn concentrations.
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Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.
TL;DR: It is shown that endothelial cells have the potential to metabolically modify the LDL molecule, generating a form that is more rapidly degraded by macrophages and that is recognized by the macrophage receptor for acetylated LDL.