Journal Article10.1002/ASIA.202000911
Near-Infrared Hypocrellin Derivatives for Synergistic Photodynamic and Photothermal Therapy.
Ying Ding,Weimin Liu,Jiasheng Wu,Xiuli Zheng,Jiechao Ge,Haohui Ren,Wenjun Zhang,Chun-Sing Lee,Pengfei Wang +8 more
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TL;DR: In vitro and in vivo therapeutic results revealed that the synergetic effect of HE-PEG-NPs on PDT and photothermal therapy (PTT) could achieve a good performance and could be regarded as a promising phototheranostic agent.
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Abstract: Hypocrellin B (HB) derived from naturally produced hypocrellins has attracted considerable attention in photodynamic therapy (PDT) because of its excellent photosensitive properties. However, the weak absorption within a "phototherapy window" (600-900 nm) and poor water solubility of HB have limited its clinical application. In this study, two HB derivatives (i. e., HE and HF) were designed and synthesized for the first time by introducing two different substituent groups into the HB structure. The obtained derivatives showed a broad absorption band covering the near-infrared (NIR) region, NIR emission (peaked at 805 nm), and singlet oxygen quantum yields of 0.27/0.31. HE-PEG-NPs were also prepared using 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) to achieve excellent dispersion in water and further explored their practical applications. HE-PEG-NPs not only retained their 1 O2 -generating ability, but also exhibited a photothermal conversion efficiency of 25.9%. In vitro and in vivo therapeutic results revealed that the synergetic effect of HE-PEG-NPs on PDT and photothermal therapy (PTT) could achieve a good performance. Therefore, HE-PEG-NPs could be regarded as a promising phototheranostic agent.
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Citations
Recent advances in magnetic nanocarriers for tumor treatment.
Jia Jun Zhu,Jian Wang,Yi-Ping Li +2 more
- 11 Jan 2023
TL;DR: Magnetic nanocarriers have become an advanced platform for tumor treatment due to their wide application in magnetic resonance imaging (MRI), biocatalysis, magneto-thermal therapy (MHT), and photoresponsive therapy as mentioned in this paper .
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Recent Developments in Heteroatom/Metal-Doped Carbon Dot-Based Image-Guided Photodynamic Therapy for Cancer
Rajkumar Krishnasamy Sekar,Nagaraj Basavegowda,Saktishree Jena,Santhoshkumar Jayakodi,P. Elumalai,Amballa Chaitanyakumar,Prathap Somu,Kwan-Hyun Baek +7 more
TL;DR: In this paper , the authors discuss the current developments in different types of heteroatom elements/metal ion-doped carbon nanodots along with their preparations, physicochemical and biological properties, multimodal-imaging, and emerging applications in image-guided photodynamic therapies for cancer.
Near-infrared upper phenyl-fused BODIPY as a photosensitizer for photothermal-photodynamic therapy.
T. Yu,Dongxiang Zhang,Jie Wang,Chang‐Liang Sun,Tianfang Cui,Zhangrun Xu,Xin Jiang,Jianjun Du +7 more
TL;DR: In this article, an upper ring-fused BODIPY with 4-dimethylaminostyryl groups (BBDP) was designed and synthesized for photothermal-photodynamic therapy.
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Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy
TL;DR: In this article , the authors review recent progress in the designs, fabrication, and applications of photoactive near-infrared CDs (PNCDs) in cancer photodynamic therapy and provide insights of future directions in accelerating the clinical progress of PNCDs.
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A novel hypocrellin-based assembly for sonodynamic therapy against glioblastoma.
Chuangli Zhang,Mrityunjay Athreya,Ping Xiao,Jiasheng Wu,Weimin Liu,Xiuli Zheng,Wenjun Zhang,Chun-Sing Lee,Pengfei Wang +8 more
TL;DR: In this paper, a suitable assembly based on a hypocrellin derivative (CTHB) with good biocompatibility was proposed for non-invasive treatment of glioblastoma (GBM).
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References
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
TL;DR: It is believed that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve the ability to combat cancers.
Mechanisms in photodynamic therapy: part one—-photosensitizers, photochemistry and cellular localization
TL;DR: The most important factor governing the outcome of PDT is how the PS interacts with cells in the target tissue or tumor, and the key aspect of this interaction is the subcellular localization of the PS.
1.9K
New photosensitizers for photodynamic therapy
TL;DR: The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery, and future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.
Overcoming the Achilles' heel of photodynamic therapy.
TL;DR: It is highly expected that deep PDT will be developed as a versatile, depth/oxygen-independent and minimally invasive strategy for treating a variety of malignant tumours at deep locations.
1.4K
Copper selenide nanocrystals for photothermal therapy.
Colin M. Hessel,Varun P. Pattani,Michael R. Rasch,Matthew G. Panthani,Bonil Koo,James W. Tunnell,Brian A. Korgel +6 more
TL;DR: In vitro photothermal heating of Cu(2-x)Se nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 min of laser irradiation at 33 W/cm(2), demonstrating the viabilitiy of Cu
1.3K