NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022.
Jimmy J. Caudell,Maura L. Gillison,Ellie Maghami,Sharon A. Spencer,David G. Pfister,Douglas Adkins,Andrew C. Birkeland,David M. Brizel,Paul M. Busse,Anthony J. Cmelak,A. Dimitrios Colevas,David W. Eisele,Thomas J. Galloway,Jessica L. Geiger,Robert I. Haddad,Wesley L. Hicks,Ying J. Hitchcock,Antonio Jimeno,Debra S. Leizman,Loren K. Mell,Bharat B. Mittal,Harlan A. Pinto,James W. Rocco,Cristina Rodríguez,Panayiotis Savvides,David L. Schwartz,Jatin P. Shah,David J. Sher,Maie A. St. John,Randal S. Weber,Gregory S. Weinstein,Frank Worden,J. Yang Bruce,Sue S. Yom,Weining Zhen,Jennifer L. Burns,Susan Darlow +36 more
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TL;DR: The NCCN Guidelines Insights summarize the panel's most recent recommendations regarding management of HPV-positive oropharynx cancer and ongoing research in this area.
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Abstract: The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer, salivary gland cancer, and mucosal melanoma (MM) are also addressed. The specific site of disease, stage, and pathologic findings guide treatment (eg, the appropriate surgical procedure, radiation targets, dose and fractionation of radiation, indications for systemic therapy). The NCCN Head and Neck Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding management of HPV-positive oropharynx cancer and ongoing research in this area.
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Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
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TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
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Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck.
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