Journal Article10.1002/MED.2610010303
Naturally occurring quinones as potential bioreductive alkylating agents
Harold W. Moore,Richard Czerniak +1 more
216
Abstract: and Related Compounds
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Citations
Free radical formation by antitumor quinones
TL;DR: The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated and it is suggested that cardiotoxicity and skin toxicity may also be related to oxygen radical formation.
431
Redox and addition chemistry of quinoid compounds and its biological implications
Anders Brunmark,Enrique Cadenas +1 more
TL;DR: The detailed chemical mechanisms by which quinoid compounds exert cytotoxic, mutagenic and carcinogenic effects are considered individually in relation to redox cycling, alterations of thiol balance and Ca++ homeostasis, and covalent binding.
397
Mutagenicity of quinones: pathways of metabolic activation and detoxification
TL;DR: The complexity of metabolic pathways involved in the mutagenicity of quinones, a class of compounds widely distributed in nature, are shown, including a cytochrome P-450-dependent reaction, whereas danthron was converted to a highly mutagenic metabolite.
393
Understanding cancer and the anticancer activities of naphthoquinones – a review
TL;DR: The most recent applications of naphthoquinones and their derivatives in cancer drug discovery are described and the biology relevant to the design of novel naphTHoquinone anticancer agents is discussed to contribute to understanding cancer.
References
Cordeauxiachinon, ein Blattfarbstoff aus Cordeauxia edulis
TL;DR: Aus den Blattern der afrikanischen Pflanze Cordeauxia edulis (Hemsl) wurde der in Farbstoffdrusen enthaltene rote FARBstoff in kristallisierter Form isoliert as mentioned in this paper.
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Modified anthraquinones from Penicillium islandicum
J. D. Bu'Lock,J. R. Smith +1 more
TL;DR: Two new pigments from Penicillium islandicum are the partly hydrogenated catenarin derivatives 1,2,3,4,4-tetrahydro-1,2.3,5,7,8,8-TTE-6-methylanthraquinone and 1, 2,2-dihydro -2.4, 5, 8, 7, 8-TETRA-7-mETHYLENTHRAquinone as mentioned in this paper.
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