Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer.
Kannie W. Y. Chan,Michael T. McMahon,Michael T. McMahon,Yoshinori Kato,Yoshinori Kato,Guanshu Liu,Guanshu Liu,Jeff W.M. Bulte,Zaver M. Bhujwalla,Zaver M. Bhujwalla,Dmitri Artemov,Dmitri Artemov,Peter C.M. van Zijl,Peter C.M. van Zijl +13 more
TL;DR: The goal was to explore the possibility of using simple D‐glucose as an infusable biodegradable MRI agent for cancer detection.
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Abstract: Purpose:
Modern imaging technologies such as CT, PET, SPECT, and MRI employ contrast agents to visualize the tumor microenvironment, providing information on malignancy and response to treatment. Currently, all clinical imaging agents require chemical labeling, i.e. with iodine (CT), radioisotopes (PET/SPECT), or paramagnetic metals (MRI). The goal was to explore the possibility of using simple D-glucose as an infusable biodegradable MRI agent for cancer detection.
Methods:
D-glucose signals were detected using chemical exchange saturation transfer (glucoCEST) MRI of its hydroxyl groups. Feasibility was established in phantoms as well as in vivo using two human breast cancer cell lines, MDA-MB-231 and MCF-7, implanted orthotopically in nude mice. PET and contrast-enhanced MRI were also acquired.
Results:
Both tumor types exhibited significant glucoCEST signal enhancement during systemic sugar infusion (mild hyperglycemia), allowing their noninvasive visualization. GlucoCEST showed differences between types, while PET and CE-MRI did not. Data are discussed in terms of signal contributions from the increased vascular volume in tumors and especially from the acidic extracellular extravascular space (EES), where glucoCEST signal is expected to be enhanced due to a slow down of hydroxyl proton exchange.
Conclusions:
This observation opens up the possibility for using simple non-toxic sugars as contrast agents for cancer detection with MRI by employing hydroxyl protons as a natural label. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
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Citations
Joint K‐space and Image‐space Parallel Imaging (KIPI) for accelerated chemical exchange saturation transfer acquisition
TL;DR: In this article , an auto-calibrated technique by joint K-space and image-space parallel imaging (KIPI) for accelerated CEST acquisition was developed for the first time.
Highly accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling.
Yi Zhang,Hye Young Heo,Shanshan Jiang,Dong-Hoon Lee,Paul A. Bottomley,Jinyuan Zhou,Jinyuan Zhou +6 more
TL;DR: It is tested whether SLAM can be adapted to significantly accelerate CEST acquisitions and provide compartmental measures with dramatically reduced scan time and optimal signal‐to‐noise ratios.
Molecular imaging of tumors by chemical exchange saturation transfer MRI of glucose analogs
Michal Rivlin,Gil Navon +1 more
TL;DR: Preclinical data may help strengthen the translation of CEST MRI of glucose analogs into the clinic, improving cancer imaging to enable early intervention without the need for invasive techniques, and broaden the knowledge of fundamental biological processes.
Challenges in glucoCEST MR body imaging at 3 Tesla.
Mina Kim,F Torrealdea,Sola Adeleke,Marilena Rega,Vincent Evans,Teresita Beeston,Katerina Soteriou,Stefanie Thust,Aaron Kujawa,Sachi Okuchi,Elizabeth Isaac,Wivijin Piga,Jonathan Lambert,Asim Afaq,Eleni Demetriou,Pratik Choudhary,King K Cheung,Sarita Naik,David Atkinson,Shonit Punwani,Xavier Golay +20 more
TL;DR: It is concluded that glucose-related signal remains elusive at 3 T in body regions, where physiological movements and strong effects of B1 + and B0 render the originally small glucoCEST signal difficult to detect.
Transverse relaxation of cerebrospinal fluid depends on glucose concentration.
Alexia Daoust,S Dodd,Govind Nair,Nadia Bouraoud,Steven Jacobson,Stuart Walbridge,Daniel S. Reich,Alan P. Koretsky +7 more
TL;DR: This study opens the possibility of monitoring glucose regulation of CSF at the resolution of MRI by quantitating T2, showing that an acute change in CSF glucose by infusion of glucose into the blood, can be monitored via changes inCSF T2 values.
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