Open AccessJournal Article
Nasopharyngeal carcinoma (NPC) mortality rate in two districts of Guangdong Province and their relation to IgA antibody level against EB virus capsid antigen
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TL;DR: The authors assume that activation of infected EB virus might be an important factor in the process of etiology-pathogenesis of NPC.
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Abstract: Based upon the retrospective investigation data, the NPC mortality rate in the Pearl River Delta was found to be twice as high as that of Chaoshan district. The positive rate of IgA/VCA antibody in the Pearl River Delta was also found to be significantly higher than that in the Chaoshan district by viro-serological screening. The IgA/VCA antibody positive rate and mortality rate were concomitantly increased with age in the bracket of 30-59. Accordingly, the authors assume that activation of infected EB virus might be an important factor in the process of etiology-pathogenesis of NPC.
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Citations
Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum.
Weimin Cheng,Kwok-Hung Chan,Honglin Chen,Rui-xian Luo,S. Park Ng,Winsie Luk,Bo-Jian Zheng,Mingfang Ji,Jin-sheng Liang,Jonathan S.T. Sham,De-kun Wang,Yong-Sheng Zong,Mun-Hon Ng +12 more
TL;DR: Evaluated EBV ELISA tests for the diagnosis of nasopharyngeal carcinoma showed that relative risk of NPC sustained by apparently healthy subjects residing in a high incidence area for NPC in the Pearl River estuary in Southern China may vary according to EBV antibody spectrum.
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Clinicopathological characteristics and prognosis of breast cancer patients with type 2 diabetes mellitus
TL;DR: T2DM BC patients were significantly older and more likely to be overweight, and had more lymph nodes involvement, and T2DM was associated with poor prognosis in ER/PR positive or Her-2-negative BC patients.
A follow-up survey of 42 048 subjects tested with Epstein-Barr viral serology in a high-incidence area of nasopharyngeal carcinoma
Ji Mingfang,Ou Xing-Tai,Zong Yong-sheng,Zheng Shou-Ang,Guo Yuan-Qing,Liang Jin-Sheng,Cheng Weimin,Wang Dekun +7 more
TL;DR: The results reveal that EBV serology could actually detect early-stage NPCs as previously reported, and the NPC risk increased 12 times the VCA-IgA-negative subjects in the V CA-IGA-positive subjects after the first-turn serological screening.
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Evaluation of combined EBNA1-IgA and EA-IgG assays in serological diagnosis of nasopharyngeal carcinoma
Zhang Chang-qing,Zong Yong-sheng,Sun Yun,Zhang Yu,Lin Suxia,Ye Yong-zhao,Feng Kai-tao,Liang Ying-jie +7 more
TL;DR: Though high sensitivity and specificity could be obtained by EBNA1-IgA and EA-IGG test, respectively, the combined use of these 2 tests is able to enhancing the reliability of serological diagnosis of NPC.