Journal Article10.1038/NRD1494
Nanosuspensions in drug delivery
1.5K
TL;DR: Water insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future, and additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated.
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Abstract: A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions. In the process of overcoming issues involving solubility, additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated. As such, insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future.
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References
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
16.8K
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
3.7K
•Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
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3.6K
Solid lipid nanoparticles: Production, characterization and applications
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TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
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•Book
Handbook of industrial crystallization
Allan S. Myerson
- 01 Jan 2002
TL;DR: Solutions and Solution Properties Crystals, Crystal Growth, and Nucleation The Influence of Impurities and Solvents on Crystallization Analysis and Measurement of Crystallisation Utilizing the Population Balance Crystallizer Selection and Design Precipitation Processes Melt and Mixing:Understanding and Modelingcrystallizer mixing andsuspension flow control of crystallization processes Processes Batch and Multi-batchCrystallization:
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