Patent
Nanopore functionality control
Ulrich F. Keyser,Nicholas A. W. Bell,Tim Liedl,Marc Ablay,Caterina Ducati +4 more
- 06 Dec 2012
16
TL;DR: In this article, a method of controlling the functionality of a substrate containing at least one nanopore is presented. But the method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrategies with the aperture aligned with the nanopores such that the sleeve formation lines the nanopORE; and expelling the molecular constructs from the substrate by varying the potential
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Abstract: A method is provided of controlling the functionality of a substrate containing at least one nanopore. The method includes the steps of: introducing to the substrate a solution containing a molecular construct having a body formation which defines an aperture and a tail formation extending from the body formation; applying a potential difference across the substrate to thread the tail formation through the nanopore thereby docking the molecular construct to the substrate with the aperture aligned with the nanopore such that the sleeve formation lines the nanopore; and expelling the molecular construct from the substrate by varying the potential difference. A DNA construct for docking to a substrate having a nanopore is also provided, the construct having a body formation which defines an aperture, and a tail formation extending from the body formation for threading through the nanopore to dock the construct to the substrate with the aperture and nanopore in alignment.
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Citations
Patent
Selective modification of polymer subunits to improve nanopore-based analysis
Jens H. Gundlach,Andrew H. Laszlo,Ian M. Derrington,Jeffrey G. Mandell +3 more
- 02 Sep 2014
TL;DR: In this paper, the authors present methods for selectively modifying one or more monomeric subunit(s) of a kind a pre-analyte polymer that results polymer analyte with a modified subunit.
9
Patent
Nanopore-based analysis of protein characteristics
Jens H. Gundlach,Ian M. Derrington,Andrew H. Laszlo,Jonathan M. Craig,Henry Brinkerhoff +4 more
- 26 Nov 2014
TL;DR: In this article, the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer, is addressed.
7
Patent
Droplet interfaces in electro-wetting devices
Matthew Holden,Ken Healy +1 more
- 24 May 2019
TL;DR: In this article, a droplet interface is formed between droplets in an electrowetting device comprising an array of actuation electrodes, where actuation signals are applied to selected actuation sensors to place the droplets into an energized state in which the shape of the droplet is modified compared to a shape of a lower energy state.
5
Patent
DNA origami nanostructure-based method for manufacturing mask
Chen Hong,Xiao Daiqin +1 more
- 23 Nov 2018
TL;DR: In this paper, a DNA origami nanostructure-based method for manufacturing a mask and relates to the field of nano-manufacturing is described. And the method comprises the steps of modifying a substrate by using a silanation reagent and making a terminal group of a monomolecular layer on the surface of the substrate be an inert group methyl.
Patent
Compositions and methods for improving nanopore sequencing
Jens H. Gundlach,Andrew H. Laszlo +1 more
- 02 Aug 2013
TL;DR: In this paper, the authors provide methods and reagents for improving nanopore-based analyses of polymers, including a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety.
References
Folding DNA to create nanoscale shapes and patterns
TL;DR: This work describes a simple method for folding long, single-stranded DNA molecules into arbitrary two-dimensional shapes, which can be programmed to bear complex patterns such as words and images on their surfaces.
Characterization of individual polynucleotide molecules using a membrane channel
TL;DR: It is shown that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane, which could in principle provide direct, high-speed detection of the sequence of bases in single molecules of DNA or RNA.
The Potential and Challenges of Nanopore Sequencing
Daniel Branton,David W. Deamer,Andre Marziali,Hagan Bayley,Steven A. Benner,Thomas Z. Butler,Massimiliano Di Ventra,Slaven Garaj,Andrew Hibbs,Xiaohua Huang,Stevan B Jovanovich,Predrag S Krstic,Stuart Lindsay,Xinsheng Sean Ling,Carlos H. Mastrangelo,Amit Meller,John S. Oliver,Yuriy V. Pershin,J. Michael Ramsey,Robert Riehn,Gautam V. Soni,Vincent Tabard-Cossa,Meni Wanunu,Matthew Wiggin,Jeffery A. Schloss +24 more
TL;DR: A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility.
Self-assembly of DNA into nanoscale three-dimensional shapes
Shawn M. Douglas,Hendrik Dietz,Tim Liedl,Björn Högberg,Franziska Graf,Franziska Graf,William M. Shih,William M. Shih +7 more
TL;DR: This work demonstrates the design and assembly of nanostructures approximating six shapes—monolith, square nut, railed bridge, genie bottle, stacked cross, slotted cross, and heterotrimeric wireframe icosahedra with precisely controlled dimensions.
Microfluidic large scale integration
TL;DR: The fluidic multiplexor as discussed by the authors is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs.
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