Book Chapter10.1007/978-3-319-41129-3_2
Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications
Saurabh Bhatia
- 01 Jan 2016
- pp 33-93
389
TL;DR: The present chapter summarizes the types of nanopharmaceuticals with the most important applications and nanoparticles associated health risk related information available till present.
read more
Abstract: The most emerging branch in pharmaceutical sciences known as “Pharmaceutical nanotechnology” presents new tools, opportunities and scope, which are expected to have significant applications in disease diagnostics and therapeutics. Recently nano-pharamceuticals reveal enormous potential in drug delivery as carrier for spatial and temporal delivery of bioactive and diagnostics. Additionally it also provides smart materials for tissue engineering. This discipline is now well-established for drug delivery, diagnostics, prognostic and treatment of diseases through its nanoengineered tools. Some nanotech based products and delivery systems are already in market. Pharmaceutical nanotechnology comprised of nano-sized products which can be transformed in numerous ways to improve their characteristics. Drugs that are transformed in to nano range offer some unique features which can lead to prolonged circulation, improved drug localization, enhanced drug efficacy etc. Various pharmaceutical nanotechnology based systems which can be termed as nanopharmaceuticals like polymeric nanoparticles, magnetic nanoparticles, liposomes, carbon nanotubes, quantum dots, dendrimers, metallic nanoparticles, polymeric nanoparticles, etc. have brought about revolutionary changes in drug delivery as well as the total medical service system. With the aid of nanopharmaceuticals, Pharmaceutical nanotechnology could have a profound influence on disease prevention to provide better insights into the molecular basis of disease. However some recently found health risk evidences limits their utilization in pharmaceutical industry. Some concerning issues like safety, bioethical issues, toxicity hazards, physiological and pharmaceutical challenges get to be resolved by the scientists. Current researchers are still lacking sufficient data and guidelines regarding safe use of these nanotechnology based devices and materials. Therefore pharmaceutical nanotechnology is still in infancy. The present chapter summarizes the types of nanopharmaceuticals with the most important applications and nanoparticles associated health risk related information available till present.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles.
TL;DR: This review attempts to shed light on some of the studies carried out on the different possible uptake pathways of nanoparticles and intracellular trafficking routes and the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanop particles.
Therapeutic Nanoparticles and Their Targeted Delivery Applications.
TL;DR: Understanding of the characteristics of nanoparticles and their interactions with the biological environment will enable us to establish novel strategies for the treatment, prevention, and diagnosis in many diseases, particularly untreatable ones.
Carbon-based nanomaterials as an emerging platform for theranostics
TL;DR: Carbon-based nanomaterials emerge as promising platforms for theranostic applications in disease treatment and tissue repair.
423
Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
TL;DR: A comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles are provided.
Use of Nanoparticles in Tissue Engineering and Regenerative Medicine.
Milad Fathi-Achachelouei,Helena Knopf-Marques,C E R Silva,Julien Barthes,Erhan Bat,Aysen Tezcaner,Nihal Engin Vrana +6 more
TL;DR: The use of NP systems in TERM is covered and an outlook for future potential use of such systems is provided.
References
Helical microtubules of graphitic carbon
TL;DR: Iijima et al. as mentioned in this paper reported the preparation of a new type of finite carbon structure consisting of needle-like tubes, which were produced using an arc-discharge evaporation method similar to that used for fullerene synthesis.
43.1K
Solid C60: a new form of carbon
TL;DR: In this article, a new form of pure, solid carbon has been synthesized consisting of a somewhat disordered hexagonal close packing of soccer-ball-shaped C60 molecules.
7.5K
In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
Nanoparticle therapeutics: an emerging treatment modality for cancer
TL;DR: The features of nanoparticle therapeutics that distinguish them from previous anticancer therapies are highlighted, and how these features provide the potential for therapeutic effects that are not achievable with other modalities are described.
4.3K
Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
3.7K