Journal Article10.1002/adhm.202400615
Nanomaterials: Recent Advances in Knee Osteoarthritis Treatment
YuFeng Peng,Sheng Wang,Ru Bai,Kejian Shi,Huige Zhou,Chunying Chen +5 more
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TL;DR: Recent advances in nanomaterials show promise in treating knee osteoarthritis, addressing current therapy limitations, and offering a potential solution to overcome inefficiency, adverse effects, and brief duration of action in knee OA treatment.
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Abstract: Osteoarthritis (OA) of the knee is the most prevalent degenerative joint condition that places a substantial financial and medical burden on society. However, due to drawbacks such as inefficiency, adverse effects, and brief duration of action, the clinical efficacy of the current major therapies for knee OA is largely restricted. Therefore, novel medication development is highly required to address these issues. Numerous studies in recent years have established that nanomaterials can be a potential and highly effective way to overcome these challenges. In this review, the anatomical distinctions between healthy and OA knee joints, as well as novel advances in the field of nanomaterials for the treatment of knee OA are summarized. The limits of the present therapeutic strategies for treating knee OA are also highlighted, as well as the potential prospects of nanomaterials in the future.
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Citations
Identification of biomarkers related to autophagy in osteoarthritis via bioinformatics analysis and experimental validation (Preprint)
Enhong Song,Gang‐Ming Zou,Chong Shen,Ridong Huang,Jianglei Yu,Qingjun Wei +5 more
- 07 Nov 2024
TL;DR: This study identifies biomarkers related to autophagy in osteoarthritis via bioinformatics analysis and experimental validation, pinpointing BCL2L1, GABARAPL2, and CTSB as promising therapeutic targets for OA treatment with potential diagnostic value.
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway
LIShi-jie,Junnan Liu,Zaishi Zhu,Zeling Huang,Yujiang Liu,Guanhong Liu,Xiaofeng Shen,Yuwei Li,Xiaoqing Shi,LIShi-jie,Junnan Liu,Zaishi Zhu,Zeling Huang,Yujiang Liu,Guanhong Liu,Xiaofeng Shen,Yuwei Li,Xiaoqing Shi +17 more
Abstract: ABSTRACT To explore the mechanism of pharmacological action of Isoimperatorin (ISO), a small molecule compound with anti‐inflammatory properties extracted from the rhizome of Notopterygium incisum , in attenuating synovial inflammation in knee osteoarthritis (KOA). By establishing a rat model of KOA and using histopathology and molecular biology methods, we evaluated the pharmacological effect of ISO on synovitis. Synovial fluid from the knee joint was collected for transcriptomic and metabolomic analyses. Fibroblast‐like synoviocytes were cultured in vitro, and calcium fluorescence imaging and mitochondrial membrane potential assays were performed to assess the effects of ISO on the cAMP signalling pathway and KOA‐related synovial inflammation. Preliminary pharmacodynamic observations showed that ISO was able to reduce synovial inflammation in KOA rats. Further transcriptomic findings in synovial tissues indicated that the mechanism of action of ISO was related to the cAMP signalling pathway and calcium ion signalling pathway. The results of metabolomics showed that the progression of synovial fibrosis was related to the abnormal metabolism of glycerophospholipids, and the intervention of ISO could significantly promote the metabolism of glycerophospholipids in synovial tissues. Finally, the results of in vitro experiments showed that ISO improved the level of inflammation and the degree of fibrosis in synovial cells, activated the cAMP signalling pathway and promoted PPAR expression, whereas inhibition of the activation of the cAMP signalling pathway attenuated the effects of ISO. ISO promotes PPAR function by upregulating the cAMP signalling pathway to modulate glycerophospholipid metabolism, thereby alleviating synovial inflammation and slowing fibrosis progression in KOA.
Progress of Micro/Nanomotors for In Vivo Biomedical Applications
Yang Su,Xue Yuan,Qijing DU,Hongning Jiang,Rongwei Han,Yongxin Yang,Chang-yong Gao,Rongbo Fan,Yang Su,Xue Yuan,Qijing DU,Hongning Jiang,Rongwei Han,Yongxin Yang,Chang-yong Gao,Rongbo Fan +15 more
TL;DR: This review summarizes the progress of micro/nanomotors (MNMs) for in vivo biomedical applications, highlighting their potential for precision medicine through targeted delivery, penetration of physiological barriers, and controlled movement in vivo for various therapeutic and diagnostic applications.
References
Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis: The CLASS Study: A Randomized Controlled Trial
Fred E. Silverstein,Gerald A. Faich,Jay L. Goldstein,Lee S. Simon,Theodore Pincus,Andrew Whelton,Robert W. Makuch,Glenn M. Eisen,Naurang M. Agrawal,William F. Stenson,Aimee M. Burr,William W. Zhao,Jeffrey D. Kent,James B. Lefkowith,Kenneth M. Verburg,G. Steven Geis +15 more
TL;DR: In this study, celecoxib, at dosages greater than those indicated clinically, was associated with a lower incidence of symptomatic ulcers and ulcer complications combined, as well as other clinically important toxic effects, compared with NSAIDs at standard dosages.
3.4K
Global, regional and national burden of osteoarthritis 1990-2017: A systematic analysis of the Global Burden of Disease Study 2017
Saeid Safiri,Ali-Asghar Kolahi,Damian G Hoy,Emma Smith,Deepti Bettampadi,Mohammad Ali Mansournia,Amir Almasi-Hashiani,Ahad Ashrafi-Asgarabad,Maziar Moradi-Lakeh,Mostafa Qorbani,Gary S. Collins,Anthony D. Woolf,Lyn March,Marita Cross +13 more
TL;DR: The global prevalence was higher in women and increased with age, peaking at the >95 age group among women and men in 2017, and a positive association was found between the age-standardised YLD rate and SDI at the regional and national levels.
1.3K
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
William H. Robinson,Christin M. Lepus,Christin M. Lepus,Qian Wang,Qian Wang,Harini Raghu,Harini Raghu,Rong Mao,Rong Mao,Tamsin M. Lindstrom,Tamsin M. Lindstrom,Jeremy Sokolove,Jeremy Sokolove +12 more
TL;DR: Osteoarthritis has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis, and increasing insight into the inflammatory underpinnings of OA holds promise for the development of new, disease-modifying therapies.
The individual and socioeconomic impact of osteoarthritis
TL;DR: This Perspectives article focuses on the burden of OA for the individual, the health-care system and society, to draw attention to the magnitude of the current problem with some reference to projected figures.
1K
Ageing and the pathogenesis of osteoarthritis
TL;DR: Improved understanding of ageing-related mechanisms that promote OA could lead to the discovery of new targets for therapies that aim to slow or stop the progression of this chronic and disabling condition.