Journal Article10.1021/CR300213B
Nanomaterials for theranostics: recent advances and future challenges.
Eun Kyung Lim,Eun Kyung Lim,Taekhoon Kim,Taekhoon Kim,Soonmyung Paik,Seungjoo Haam,Yong Min Huh,Kwangyeol Lee +7 more
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TL;DR: Challenges Eun-Kyung Lim,†,‡,§ Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh,*,† and Kwangyeol Lee
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Abstract: Challenges Eun-Kyung Lim,†,‡,§ Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh,*,† and Kwangyeol Lee* Department of Chemistry, Korea University, Seoul 136-701, Korea †Department of Radiology, Yonsei University, Seoul 120-752, Korea Severance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 120-749, Korea Division of Pathology, NSABP Foundation, Pittsburgh, Pennsylvania 15212, United States Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea ‡BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea Electronic Materials Laboratory, Samsung Advanced Institute of Technology, Mt. 14-1, Nongseo-Ri, Giheung-Eup, Yongin-Si, Gyeonggi-Do 449-712, Korea
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Citations
Novel Biorecognition Elements against Pathogens in the Design of State-of-the-Art Diagnostics.
Maria G. Sande,Joana Lúcia Lima Correia Rodrigues,Débora Ferreira,Carla J. S. M. Silva,Lígia R. Rodrigues +4 more
TL;DR: A review of the latest developments regarding biorecognition elements and strategies to use them in the design of new biosensors for pathogens detection is reviewed in this paper, where the authors present a method to identify the causative pathogen using chemical ligands, molecularly imprinted polymers and Clustered Regularly Interspaced Short Palindromic Repeats-associated nuclease.
Construction of synergistic pH/H2O2-responsive prodrug for prolonging blood circulation and accelerating cellular internalization
TL;DR: In this article , a real-time and multifunctional doxifluridine-conjugate prodrug (LYX) was developed, which involved the preliminary methylfluorescein with 5-fluorouracil linker as protecting group, the targeting biotin unit, and a model therapeutic drug (doxifi luridine) was found to be effective in prolonging circulation at physiological pH 7.4 and improving accumulation in the acidic microenvironment of the tumor.
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