Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea.
Juarana Dal Mas,Tailyn Zermiani,Liliani Carolini Thiesen,Joana Lm Silveira,Kathryn Abs da Silva,Márcia Maria de Souza,Angela Malheiros,Tania Mb Bresolin,Ruth M. Lucinda-Silva +8 more
TL;DR: An extract-loaded nanoemulsion containing soft extract of stem bark of Rapanea ferruginea showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity.
read more
Abstract: The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was -34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 μg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Nanoemulsions containing Cymbopogon flexuosus essential oil: Development, characterization, stability study and evaluation of antimicrobial and antibiofilm activities.
Samanta da Silva Gündel,Márcia Ebling de Souza,Priscilla Maciel Quatrin,Bruna Klein,Roger Wagner,André Gündel,Rodrigo de Almeida Vaucher,Roberto Christ Vianna Santos,Aline Ferreira Ourique +8 more
TL;DR: Results are very promising because among the microorganisms that the nanoemulsion containing C. flexuosus was able to inhibit the formation of biofilm are the bacteria Pseudomonas aeruginosa and Staphylococcus aureus, which were recently listed by the World Health Organization as priority pathogens for development of new antibiotics.
92
Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation.
TL;DR: It can be concluded that the topical gel loaded with transfersomal lidocaine shows enhanced skin permeation effect along with increase in local anesthetic action of lidocane.
Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis.
Yao-Xing Dou,Jiang-Tao Zhou,Tong-Tong Wang,Yan-Feng Huang,Vicky Ping Chen,You-Liang Xie,Zhi-Xiu Lin,Jian-Sheng Gao,Zi-Ren Su,Hui-Fang Zeng +9 more
TL;DR: BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model.
Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview
TL;DR: In this paper , the suitability of nano-formulation for a particular type of extracts or enriched fraction of phytoconstituents based on their solubility and permeability profile (similar to the BCS class of drugs).
46
The role of bioactive phytoconstituents-loaded nanoemulsions for skin improvement: a review
TL;DR: As the largest organ in the human body, the skin should be protected from various harmful chemicals and pollutants from the surrounding environment and ultraviolet (UVA/UVB) radiation emitted from...
34
References
Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
TL;DR: It is demonstrated that MPO can be used as a marker for skin neutrophil content: it is recoverable from skin in soluble form, and is directly related to neutrophIL number.
3.6K
Formation and stability of nano-emulsions
TL;DR: This review describes the principles of formation and stability of nano-emulsions, namely high energy emulsification (using homogenisers), low energy emulsion preparation, and the principle of the phase inversion temperature (PIT), and the role of the adsorbed layer thickness.
1.9K
Oxidative stress in the pathogenesis of skin disease.
David R. Bickers,Mohammad Athar +1 more
TL;DR: One approach to preventing or treating these ROS-mediated disorders is based on the administration of various antioxidants in an effort to restore homeostasis.
1K
Nanoemulsions: formation, structure, and physical properties
TL;DR: In this article, the authors summarize procedures for producing nanoemulsions comprised of nanoscale droplets, methods for controlling the droplet size distribution and composition, and interesting physical properties of nanoEMulsions.
982
TOPICAL REVIEW: Nanoemulsions: formation, structure, and physical properties
TL;DR: In this article, the authors summarize procedures for producing nanoemulsions comprised of nanoscale droplets, methods for controlling the droplet size distribution and composition, and interesting physical properties of nanoEMulsions.
912