Journal Article10.1016/J.EJPB.2011.12.015
Nanocrystals: comparison of the size reduction effectiveness of a novel combinative method with conventional top-down approaches
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TL;DR: It was shown that the combinative approach can significantly improve the particle size reduction effectiveness of both top-down methods over conventional approaches.
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About: This article is published in European Journal of Pharmaceutics and Biopharmaceutics. The article was published on 01 May 2012. The article focuses on the topics: Particle size.
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Citations
Bottom-up approaches for preparing drug nanocrystals: formulations and factors affecting particle size.
TL;DR: The bottom-up approach has not yet been established as a successful commercial technology, however, it has the potential to produce small size drug nanocrystals with less energy demanding processes.
478
Overview of milling techniques for improving the solubility of poorly water-soluble drugs
TL;DR: Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a "top-down" approach in the production of fine particles as mentioned in this paper.
456
Drug nanocrystals in the commercial pharmaceutical development process
TL;DR: All major pharmaceutical companies have realized the potential of drug nanocrystals and included this universal formulation approach into their decision trees and nanosuspensions are currently used at all stages of commercial drug development.
390
Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals - A comprehensive review.
Luis Padrela,Miguel Rodrigues,Andreia Duarte,Ana M.A. Dias,Mara E.M. Braga,Hermínio C. de Sousa +5 more
TL;DR: A comprehensive state‐of‐the‐art review on scCO2‐based processes focused on the formation and on the control of the physicochemical, structural and morphological properties of amorphous/crystalline pure drug nanoparticles.
218
Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation⁻Processing Aspects and Challenges.
TL;DR: This review provides rationale and guidance for drying process selection and robust nanocomposite formulation development, with insights into the roles of various classes of dispersants.
186
References
Practical aspects of lyophilization using non-aqueous co-solvent systems.
Dirk L. Teagarden,David S. Baker +1 more
TL;DR: The co-solvent system that has been most extensively evaluated was the tert-butanol/water combination, which freezes completely in most commercial freeze-dryers, and has been used in the manufacture of a marketed injectable pharmaceutical product.
218
A novel bottom-up process to produce drug nanocrystals : Controlled crystallization during freeze-drying
TL;DR: To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze drying which allows for the production of nanocrystalline particles was developed: "controlled crystallization during freeze drying".
174
New method for the effective production of ultrafine drug nanocrystals.
TL;DR: It could be shown that modified hydrocortisone acetate was particularly suitable to be further processed by high pressure homogenization and obtained nanosuspensions, which have shown excellent long-term storage stability.
106
Application of formulation technologies in lead candidate selection and optimization
TL;DR: In this paper, the authors proposed a platform for the formulation of poorly soluble drugs using nanoparticles, which can be injected (intravenous, subcutaneous, intramuscular), as well as administered through other routes, such as oral, ocular and inhalation.
79
A Consensus Neural Network-Based Technique for Discriminating Soluble and Poorly Soluble Compounds
David T. Manallack,Benjamin G Tehan,Emanuela Gancia,Brian D Hudson,Martyn G Ford,David J. Livingstone,David C. Whitley,William R. Pitt +7 more
TL;DR: This paper presents studies of consensus neural networks trained on BCUTs to discriminate compounds with poor aqueous solubility from those with reasonablesolubility, intended to be used as a filter in the selection of screening candidates, compound purchases, and the application of synthetic priorities to combinatorial libraries.
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