Open Access
Nanocarriers as an emerging platform for cancer therapy
S. Wise
- 01 Jan 2007
1.2K
About: The article was published on 01 Jan 2007. and is currently open access. The article focuses on the topics: Nanocarriers.
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Citations
Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted anticancer drug delivery
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TL;DR: DIAs were confirmed to have a potent antitumor efficacy while reducing tissue deformation and apoptosis in the heart, thus providing a new therapeutic avenue to prevent cardiomyopathy, the most dangerous side effect of doxorubicin leading to heart failure.
Theranostic nanoparticles for cancer and cardiovascular applications.
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Lipid-based nanosystems for CD44 targeting in cancer treatment: recent significant advances, ongoing challenges and unmet needs
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TL;DR: Insight is provided in tailoring particle modification by HA in order to design more efficient CD44-targeting lipid nanocarriers, and tries to understand how these modifications influence particle physicochemical properties, interaction with CD44 receptors, intracellular trafficking pathways, toxicity, complement/macrophage activation and pharmacokinetics.
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Preparation of HIFU-triggered tumor-targeted hyaluronic acid micelles for controlled drug release and enhanced cellular uptake
Shaohui Zheng,Zhen Jin,Jiwon Han,Sunghoon Cho,Van Du Nguyen,Seong Young Ko,Jong-Oh Park,Sukho Park +7 more
TL;DR: The present study demonstrates that the micelles prepared in this study can emerge as promising nanocarriers of chemotherapeutic agents for controlled drug release and tumor targeting in cancer treatment.
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Progress in siRNA delivery using multifunctional nanoparticles.
TL;DR: This chapter reviews recent progress using a multifunctional approach to design and engineer polymeric nanoparticles for siRNA delivery.
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References
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Recent advances with liposomes as pharmaceutical carriers.
TL;DR: For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.
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Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
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Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Leon R. Hirsch,R.J. Stafford,James A. Bankson,S.R. Sershen,Belinda Rivera,Roger E. Price,John D. Hazle,Nancy J. Halas,Jennifer L. West +8 more
TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
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