Nanocarriers as an emerging platform for cancer therapy

TL;DR: The current opinions on bone marrow vasculature, as well as the molecular and structural interactions between tumor cells and the diseased bone marrow are presented, which can improve the efficacy of therapeutic agents and reduce their dose-limiting systemic side effects on healthy tissues.

TL;DR: In this article, the authors obtained adriamycin-loaded polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody (PLNP-Mal-EGFR) for hepatocellular carcinoma (HCC) chemotherapy.

TL;DR: This review focuses on the sncRNA functions and recent advances on the delivery of these molecules by biodegradable, biocompatible and nontoxic biopolymers including chitosan, cyclodextrins, poly-l-lysine, dextran, poly (lactic co-glycolic acid), polyglutamic acid, hyaluronic acid and gelatin.

TL;DR: This study presents a nanofabricated platform able to perform intracellular delivery of membrane-impermeable molecules by opening transient nanopores into the lipid membrane of adherent cells with high spatial precision and with the application of low voltages.

TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.

TL;DR: For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.

TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.

TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.