Open Access
Nanocarriers as an emerging platform for cancer therapy
S. Wise
- 01 Jan 2007
1.2K
About: The article was published on 01 Jan 2007. and is currently open access. The article focuses on the topics: Nanocarriers.
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Citations
Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer
Ayrat Gizzatov,Ayrat Gizzatov,Cinzia Stigliano,Jeyarama S. Ananta,Richa Sethi,Rong Xu,Adem Guven,Maricela R. Ramirez,Haifa Shen,Anil K. Sood,Mauro Ferrari,Mauro Ferrari,Lon J. Wilson,Xuewu Liu,Paolo Decuzzi +14 more
TL;DR: Mesoporous silicon nanoconstructs with a discoidal shape and a sub-micrometer size have been conjugated with gadolinium-tetraazacyclododecane tetraacetic acid Gd(DOTA) molecules and proposed as contrast agents for Magnetic Resonance Imaging, suggesting that Gd-SiMPs could be efficiently used for MR vascular imaging in cancer and other diseases.
32
Alginate-lanthanide microspheres for MRI-guided embolotherapy.
Chris Oerlemans,Peter R. Seevinck,Gerrit H. van de Maat,Hassan Boulkhrif,Chris J.G. Bakker,Wim E. Hennink,J. Frank W. Nijsen +6 more
TL;DR: The different alginate-lanthanide microsphere formulations developed in this study show great potential for utilization as image-guided embolotherapy agents.
31
Polymersomes with Rapid K+-Triggered Drug-Release Behaviors.
TL;DR: Such K+-responsive polymersomes with the desired drug-release properties provide a novel strategy for advanced intracellular drug delivery and release, which can enhance the safety and efficacy of cancer therapy.
31
Engineering platelet-mimicking drug delivery vehicles
TL;DR: This review highlights recent advancements made in the platelet-mimicking strategies and discusses the future opportunities and translational challenges.
31
Cross-linker-Modulated Nanogel Flexibility Correlates with Tunable Targeting to a Sterically Impeded Endothelial Marker
Jacob W. Myerson,Olivia M. McPherson,Kelsey G. DeFrates,Jenna H Towslee,Oscar A. Marcos-Contreras,Vladimir V. Shuvaev,Bruce Braender,Russell J. Composto,Vladimir R. Muzykantov,David M. Eckmann +9 more
TL;DR: Atomic force microscopy and spectroscopy measurements of nanocarrier Young's moduli are presented, and tuning of specific sterically constrained vascular targeting behavior in correlation with cross-linker-modified NG mechanical properties are demonstrated.
31
References
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Recent advances with liposomes as pharmaceutical carriers.
TL;DR: For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.
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Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
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Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Leon R. Hirsch,R.J. Stafford,James A. Bankson,S.R. Sershen,Belinda Rivera,Roger E. Price,John D. Hazle,Nancy J. Halas,Jennifer L. West +8 more
TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
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