Journal Article10.1002/EJIC.201901339
N-Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds
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About: This article is published in European Journal of Inorganic Chemistry. The article was published on 09 Jan 2020. The article focuses on the topics: Carbene & Platinum.
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Citations
What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
TL;DR: In this paper, a review at the interface of chemistry, biology and medicine points out main problems for current platinum drug development from their action mechanisms, and provides up-to-date potential strategies from drug design perspectives to circumvent those drawbacks, and it is supposed to enlighten researchers with more ideas for future development of highly efficient platinum antitumor complexes.
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Platinum(IV) antitumor complexes and their nano-drug delivery
TL;DR: This overview briefly analyzes mechanisms underlying platinum biological activity and resistance, and then is concerned with the development of PtIV complexes, especially highlighting combination therapy with nanocarriers.
85
Anticancer and antibacterial properties of trinuclear Cu(I), Ag(I) and Au(I) macrocyclic NHC/urea complexes
Christian H. G. Jakob,Angela Weigert Muñoz,Jonas F. Schlagintweit,Vanessa Weiß,Robert M. Reich,Stephan A. Sieber,João D. G. Correia,Fritz E. Kühn +7 more
TL;DR: In this paper, the first macrocyclic Cu(I, Ag(I), Au(I) and tricarbene/urea N-heterocyclic carbene (NHC) complexes are described and their fluorescence properties are compared to related tetracarbene complexes.
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An overview of anticancer platinum N-heterocyclic carbene complexes
Sai Zhao,Zhibing Yang,Zhibing Yang,Guizhi Jiang,Sheng Huang,Mianli Bian,Yunlong Lu,Wukun Liu,Wukun Liu +8 more
TL;DR: In this article, N-Heterocyclic carbenes (NHCs) have been introduced as a new platform for the development of anticancer metal complexes for several decades.
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Recent advances in the synthesis and derivatization of N-heterocyclic carbene metal complexes.
TL;DR: An overview of the latest developments in N-heterocyclic carbene (NHC) metal complexes can be found in this paper, focusing on those which have appeared during the last two years.
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References
N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact.
May Wantz,Mathilde Bouché,Georges Dahm,Neila Chekkat,Sylvie Fournel,Stéphane Bellemin-Laponnaz +5 more
TL;DR: It is shown on 8 different types of cells that the activity of these conjugates is modulated by the size of the polymer and the overall density of metal ions onto polymer chains, which combines water-solubility and cytotoxicity.
Synthesis and structural characterization of alkyne-functionalized N-heterocyclic carbene complexes of ruthenium, palladium and rhodium
TL;DR: A series of novel ruthenium(II), palladium(II) and rhodium(I) complexes bearing N-heterocyclic carbene ligand functionalized by an alkyne-protected functional group were synthesized by transmetalation from the silver-NHC intermediate or by deprotonation of the azolium salt using an external base.
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A Chemoselective and Modular Post-Synthetic Multi-Functionalization of NHC–Platinum Complexes
TL;DR: In this paper, oxime ligation in combination with metal ligand exchange is proposed as a novel orthogonal and practical approach to the multifunctionalization of NHC-platinum complexes.
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[Estrogen and progestogen cytosol receptors in human breast carcinoma (author's transl)].
TL;DR: The authors have studied Estrogen (RE) and Progestin (RP) cytosol receptors in 379 human breast carcinomas and point out that high rates of RE correlate with post‐menopausal women and high rate of RP with pre‐ menopausal women, suggesting both receptors are necessary to obtain a positive response to hormonal therapy.
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Synthesis and structural characterization of benzyl-functionalized N-heterocyclic carbene platinum complexes: Dramatic substituent effect on anti-cancer activity
TL;DR: A series of platinum (II) complexes bearing N-heterocyclic carbene NHC ligands functionalized by various benzyl moieties were synthesized and characterized by X-ray diffraction studies on single crystals.
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