Journal Article10.1002/EJIC.201901339
N-Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds
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About: This article is published in European Journal of Inorganic Chemistry. The article was published on 09 Jan 2020. The article focuses on the topics: Carbene & Platinum.
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Citations
What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
TL;DR: In this paper, a review at the interface of chemistry, biology and medicine points out main problems for current platinum drug development from their action mechanisms, and provides up-to-date potential strategies from drug design perspectives to circumvent those drawbacks, and it is supposed to enlighten researchers with more ideas for future development of highly efficient platinum antitumor complexes.
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Platinum(IV) antitumor complexes and their nano-drug delivery
TL;DR: This overview briefly analyzes mechanisms underlying platinum biological activity and resistance, and then is concerned with the development of PtIV complexes, especially highlighting combination therapy with nanocarriers.
85
Anticancer and antibacterial properties of trinuclear Cu(I), Ag(I) and Au(I) macrocyclic NHC/urea complexes
Christian H. G. Jakob,Angela Weigert Muñoz,Jonas F. Schlagintweit,Vanessa Weiß,Robert M. Reich,Stephan A. Sieber,João D. G. Correia,Fritz E. Kühn +7 more
TL;DR: In this paper, the first macrocyclic Cu(I, Ag(I), Au(I) and tricarbene/urea N-heterocyclic carbene (NHC) complexes are described and their fluorescence properties are compared to related tetracarbene complexes.
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An overview of anticancer platinum N-heterocyclic carbene complexes
Sai Zhao,Zhibing Yang,Zhibing Yang,Guizhi Jiang,Sheng Huang,Mianli Bian,Yunlong Lu,Wukun Liu,Wukun Liu +8 more
TL;DR: In this article, N-Heterocyclic carbenes (NHCs) have been introduced as a new platform for the development of anticancer metal complexes for several decades.
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Recent advances in the synthesis and derivatization of N-heterocyclic carbene metal complexes.
TL;DR: An overview of the latest developments in N-heterocyclic carbene (NHC) metal complexes can be found in this paper, focusing on those which have appeared during the last two years.
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References
Exploring Nitrogen Ligand Diversity in trans‐N‐Heterocyclic Carbene–Amine Platinum Complexes : Synthesis, Characterization, and Application to Fluorescence
TL;DR: N-Heterocyclic carbene-Pt-pyridine complexes have been used to generate an expanded and diversified set of trans NHC-PT complexes with various amines, polyamines, hydroxylamines, or hydrazine as ligands.
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Exploring diversity in platinum(iv) N-heterocyclic carbene complexes: synthesis, characterization, reactivity and biological evaluation.
TL;DR: Data show that NHC-Pt(iv) compounds are good candidates as anti-cancer prodrugs, specifically against cisplatin-resistant cancer cells.
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N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction.
Sébastien Harlepp,Edith Chardon,Mathilde Bouché,Georges Dahm,Mounir Maaloum,Mounir Maaloum,Stéphane Bellemin-Laponnaz +6 more
TL;DR: A platinum (II) complex stabilized by a pyridine and an N-heterocyclic carbene ligand featuring an anthracenyl moiety demonstrated high in vitro antiproliferative activities against cancer cell lines with IC50 ranging from 10 to 80 nM.
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Synthesis, Structure and Antitumoural Activity of Triazole‐Functionalised NHC–Metal Complexes
TL;DR: In this paper, the N-heterocyclic carbene ligand has been functionalised with a 1,2,3-triazole moiety tethered in the backbone of the ligand.
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Selective Formation of cis-N-Heterocyclic Carbene-PtII-Pnictogen Complexes and in vitro Evaluation of Their Cytotoxic Activities toward Cancer Cells
Mathilde Bouché,Georges Dahm,Aline Maisse-François,Thierry Achard,Stéphane Bellemin-Laponnaz +4 more
TL;DR: A series of heterotopic platinum complexes combining N-heterocyclic carbene (NHC) and pnictogen-based ligands [Pn = P(nBu)3, PPh3, AsPh3 and SbPh3] has been synthesized and fully characterized as discussed by the authors.
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