Journal Article10.1016/J.IMBIO.2011.07.008
Mycobacterium tuberculosis: immune evasion, latency and reactivation.
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TL;DR: This article explains how the pathogen evades the host immune response to establish a latent infection, and how it emerges from a state of latency to cause reactivation disease.
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About: This article is published in Immunobiology. The article was published on 01 Mar 2012. The article focuses on the topics: Population.
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TL;DR: Using nanofiltration membranes for recovery of phosphorous with a second type of technology for the recovery of nitrogen is suggest to be a viable process.
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Mariana C Orozco-Uribe,Luis Donis-Maturano,Juana Calderón-Amador,Rommel Chacón-Salinas,J. Castañeda-Casimiro,Sergio Estrada-Parra,Iris Estrada-García,Leopoldo Flores-Romo +7 more
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Cavities create a potential back door in epoxide hydrolase Rv1938 from Mycobacterium tuberculosis-A molecular dynamics simulation study
Anitha Selvan,Sharmila Anishetty +1 more
TL;DR: Structural superimposition of epoxide hydrolase from Mtb with the epoxide Hydrolase of Agrobacterium radiobacter1 AD1 (Ephy) indicates that cavity1 in Mtb lies at an identical position to that of the water tunnel in Ephy.
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Mycobacterial resuscitation promoting factors: roles and mechanisms in infected macrophages
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- 30 Jun 2015
TL;DR: The author states that the present manuscript aims to provide a history of the field and some of the techniques used in its development, as well as some suggestions for further study, which are currently under development.
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References
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Spencer Liang,Xiang-Yang Tan,Deborah Luxenberg,Riyez Karim,Kyriaki Dunussi-Joannopoulos,Mary Collins,Lynette A. Fouser +6 more
TL;DR: IL-22 is identified as a new cytokine expressed by Th17 cells that synergizes with IL- 17A or IL-17F to regulate genes associated with skin innate immunity.
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IL-21 initiates an alternative pathway to induce proinflammatory T H 17 cells
Thomas Korn,Estelle Bettelli,Wenda Gao,Amit Awasthi,Anneli Jäger,Terry B. Strom,Mohamed Oukka,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6-deficient (Il6-/-) mice do not develop a TH17 response and their peripheral repertoire is dominated by Foxp3+ Treg cells, suggesting an additional pathway by which TH17 cells might be generated in vivo.
How can immunology contribute to the control of tuberculosis
TL;DR: A clear understanding of the immune responses that control the pathogen will be important for achieving optimal immunity, and information provided by functional genome analysis of M. tuberculosis will be vital in the design of a future vaccine.
Phagosome maturation: aging gracefully.
TL;DR: The determinants and consequences of the fusion and fission reactions that underlie phagosomal maturation are the topic of this review.
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•Journal Article
Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors.
TL;DR: Examination of macrophage receptors that mediate phagocytosis of virulent strains and an attenuated strain of the intracellular pathogen, Mycobacterium tuberculosis, finds adherence of the three strains to monocyte-derived macrophages is markedly enhanced in the presence of low levels of fresh serum.
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