Myasthenia Gravis

TL;DR: Nicotinic acetylcholine receptors (AChR) are prototypical members of the neurotransmitter-gated superfamily of ion channels (ionotropic neurotransmitter receptors; see Figure 7.1; see chapters 2,5, and 6 in this volume).

TL;DR: Patients with rapidly progressive symptoms classically suggestive of a paraneoplastic neurologic syndrome, time is of the essence in arresting neurologic deterioration, and a single cycle of PE may be considered before other treatment, to achieve rapid lowering of circulating paranoplastic autoantibodies.

TL;DR: Depression was more common in individuals with autoimmune diseases than in controls, and vice versa, and modest R2 values suggest that shared genetic architecture accounts for a small proportion of the increased risk across traits.

TL;DR: The results provide the first evidence that short-term albuterol treatment can ameliorate weakness in a robust mouse model of anti-MuSK myasthenia gravis and demonstrate that it is possible to reduce whole-body weakness without necessarily reversing myastshenic impairment to the structure and function of the neuromuscular junction.