Journal Article10.1615/INTJMEDMUSHROOMS.V18.I7.10
Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation
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TL;DR: Inhibitory properties of extracts from L. edodes on osteoclasts and the promotion of osteoblasts in vitro, together with the potential to decrease lumbar spine bone loss in an animal osteoporosis model, indicate that medicinal mushroom extracts can be considered as a preventive treatment and/or a supplement to pharmacotherapy to enhance its effectiveness and ameliorate its harmful side effects.
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Abstract: Mushroom extracts have shown promising effects in the treatment of cancer and various chronic diseases. Osteoporosis is considered one of the most widespread chronic diseases, for which currently available therapies show mixed results. In this research we investigated the in vitro effects of water extracts of the culinary-medicinal mushrooms Trametes versicolor, Grifola frondosa, Lentinus edodes, and Pleurotus ostreatus on a MC3T3-E1 mouse osteoblast-like cell line, primary rat osteoblasts, and primary rat osteoclasts. In an animal osteoporosis model, rats were ovariectomized and then fed 2 mushroom blends of G. frondosa and L. edodes for 42 days. Bone loss was monitored using densitometry (dual-energy X-ray absorptiometry) and micro computed tomography. In the concentration test, mushroom extracts showed no toxic effect on MC3T3-E1 cells; a dose of 24 µg/mL showed the most proliferative effect. Mushroom extracts of T. versicolor, G. frondosa, and L. edodes inhibited osteoclast activity, whereas the extract of L. edodes increased osteoblast mineralization and the production of osteocalcin, a specific osteoblastic marker. In animals, mushroom extracts did not prevent trabecular bone loss in the long bones. However, we show for the first time that the treatment with a combination of extracts from L. edodes and G. frondosa significantly reduced trabecular bone loss at the lumbar spine. Inhibitory properties of extracts from L. edodes on osteoclasts and the promotion of osteoblasts in vitro, together with the potential to decrease lumbar spine bone loss in an animal osteoporosis model, indicate that medicinal mushroom extracts can be considered as a preventive treatment and/or a supplement to pharmacotherapy to enhance its effectiveness and ameliorate its harmful side effects.
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Citations
Dietary supplementation with mushroom powder (Agaricus bisporus) on performance, carcass traits, meat quality, and bone biomechanical properties of quail (Coturnix coturnix japonica)
Seyit Gökmen,Kübra Ünal,Osman Olgun,Behlül Sevim,A. Sarmiento-García +4 more
TL;DR: This study investigates the effects of Agaricus bisporus mushroom powder supplementation on Japanese quail performance, carcass traits, meat quality, and bone biomechanical properties, finding improved oxidative stability and bone strength with 0.50-0.75% dietary addition.
The Medicinal Mushroom, Grifola gargal, Ameliorates Allergic Bronchial Asthma.
Etsuko Harada,Corina N. D’Alessandro-Gabazza,Masaaki Toda,Toshihiro Morizono,Toshiaki Totoki,Taro Yasuma,Kota Nishihama,Tetsu Kobayashi,Toshimitsu Sumiya,Hirokazu Kawagishi,Esteban C. Gabazza +10 more
TL;DR: Observations show that G. gargal extract augments the lung population of regulatory T cells and ameliorates allergic inflammation and airway hyperresponsiveness in mice with allergic bronchial asthma, suggesting the potential therapeutic benefit of G. Gargal extract in allergic diseases.
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TL;DR: This review examines the fundamental pathogenetic mechanisms underlying osteoporosis, which include: (a) failure to achieve a skeleton of optimal strength during growth and development; (b) excessive bone resorption resulting in loss of bone mass and disruption of architecture; and (c) Failure to replace lost bone due to defects in bone formation.
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TL;DR: Cortex and trabecular bone loss using QCT of the spine and hip in 14 crewmembers making 4‐ to 6‐month flights on the International Space Station showed no compartment‐specific loss of bone in the spine.
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TL;DR: In this paper, different definitions of osteoporosis were evaluated in a population-based sample of 348 men (age 22-90 years) compared with 351 women (age 21-93 years).
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TL;DR: The history, current status, and future trends in the study of medicinal mushrooms are analyzed to draw attention to many critically important unsolved problems in the future development of medicinal mushroom science in the 21st century.
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