Multipotent mesenchymal stromal cells are sensitive to thermic stress – potential implications for therapeutic hyperthermia
Alexander Rühle,Alexander Rühle,Andreas R. Thomsen,Andreas R. Thomsen,Rainer Saffrich,Maren Voglstätter,Maren Voglstätter,Birgit Bieber,Birgit Bieber,Tanja Sprave,Tanja Sprave,Patrick Wuchter,Peter Vaupel,Peter Vaupel,Peter E. Huber,Peter E. Huber,Anca-Ligia Grosu,Anca-Ligia Grosu,Nils H. Nicolay,Nils H. Nicolay +19 more
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TL;DR: Human MSCs exhibit a thermosensitive phenotype which reduced the multipotent cells’ regenerative abilities, resulting in impaired tissue regeneration after hyperthermia treatment or thermal injuries.
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Abstract: Purpose: Hyperthermia demonstrated clinical efficacy in multimodal cancer treatment. Multipotent mesenchymal stromal cells (MSCs) as part of the tumor-supporting stroma modulate tumor response and ...
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Citations
Current progress of mesenchymal stem cell membrane-camouflaged nanoparticles for targeted therapy.
Lianlian Fan,Anhui Wei,Zihui Gao,Xupeng Mu +3 more
- 02 Mar 2023
TL;DR: In this paper , a review of the use of mesenchymal stem cell membrane-coated nanoparticles for therapy and drug delivery, aiming to provide guidance for the design and clinical application of membrane carrier in the future.
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Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy.
Mariella Tutter,Christina Schug,Kathrin A Schmohl,Sarah Urnauer,Carolin Kitzberger,Nathalie Schwenk,Matteo Petrini,Christian Zach,Sibylle Ziegler,Peter Bartenstein,Wolfgang Weber,Gabriele Multhoff,Ernst Wagner,Lars H. Lindner,Peter J. Nelson,Christine Spitzweg,Christine Spitzweg +16 more
TL;DR: It is demonstrated here for the first time that hyperthermia can significantly boost tumoral MSC recruitment thereby significantly enhancing therapeutic efficacy of MSC-mediated NIS gene therapy.
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Mild photothermal therapy assist in promoting bone repair: Related mechanism and materials
Zehao Yu,Boda Ying,Xiaohan Mei,Dapeng Zeng,Shibo Liu,Wenrui Qu,Si Pu,Ruiyan Li +7 more
TL;DR: A comprehensive overview of the mechanisms underlying MPT is provided and a compilation of photothermal agents and their utilization strategies for bone tissue repair is presented, aiming to provide insights and recommendations for optimizing material design in this field.
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Recent advances in biomimetic cell membrane–camouflaged nanoparticles for cancer therapy
Sajjad Alimohammadvand,Sajjad Alimohammadvand,Sajjad Alimohammadvand,Sajjad Alimohammadvand,Sajjad Alimohammadvand +4 more
TL;DR: Biomimetic cell membrane–camouflaged nanoparticles for cancer therapy enhance tumor targeting and efficacy through self-recognition, homotypic targeting, and long-lasting circulation.
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Vitronectin Mediates Survival of Human WJ-MSCs Under Inflammatory Temperature Stress Via Cell Cycle Arrest
TL;DR: In this article , the role of extracellular matrix (ECM) components can mediate cell survival signals, and the authors evaluated the effect of ECM matricesllular protein, vitronectin (VTN), in the survival of mesenchymal stem cells (MSCs) under the condition of inflammatory temperature stress.
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Ramon Lopez Perez,Ramon Lopez Perez,Franziska Münz,Jonas Kroschke,Jannek Brauer,Nils H. Nicolay,Peter E. Huber +6 more
TL;DR: The presented method enables a quantitative and longitudinal analysis of the DNA damage response after genotoxic stress, as induced by radiotherapy and a multitude of anti-cancer drugs, and can be widely applied as a comprehensive genotoxicity assay in many fields of oncology besides radio-oncology, including environmental risk factor assessment, drug screening and evaluation of genetic instability in tumor cells.
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Hyperthermia on mesenchymal stem cells (MSCs) can sensitize tumor cells to undergo cell death.
TL;DR: Investigation of the effects of hyperthermia-treated MSCs on the viability and growth of cancer cells suggests that tumor stroma can enable tumorStroma provide a sensitizing environment for tumor cells to undergo cell death.
Human Mesenchymal Stromal Cells: Identifying Assays to Predict Potency for Therapeutic Selection
Desirae L. Deskins,Dikshya Bastakoty,Sarika Saraswati,Andrew A. Shinar,Ginger E. Holt,Pampee P. Young,Pampee P. Young +6 more
TL;DR: It is found that high performance in a combination of the in vitro tests accurately predicted which lines functioned well in vivo, suggesting that reliable and reproducible in vitro assays may be used to measure the functional potential of MSCs for therapeutic use.
Tumor associated mesenchymal stem cells protects ovarian cancer cells from hyperthermia through CXCL12.
Raphael Lis,Cyril Touboul,Cyril Touboul,Pejman Mirshahi,Fadoua Ali,Sharon Mathew,Daniel J. Nolan,Mahtab Maleki,Salma A. Abdalla,Christophe M. Raynaud,Denis Querleu,Eman K. Al-Azwani,Joel A. Malek,Massoud Mirshahi,Arash Rafii +14 more
TL;DR: It is demonstrated that hyperthermia does not challenge survival of TAMC or bone marrow derived MSC (BM‐MSC) and co‐cultured with OCC induced thermotolerance in a CXCL12 dependant manner, and Targeting the interaction between stromal and cancer cells through CX CL12 inhibition might restore hyperThermia sensitivity in ovarian cancers, and thus improve HIPEC efficiency.
The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity
Alexander Rühle,Alexander Rühle,Peter E. Huber,Peter E. Huber,Rainer Saffrich,Ramon Lopez Perez,Nils H. Nicolay +6 more
TL;DR: A concise review of the published data regarding the influence of various classes of chemotherapeutic agents on the survival, stem cell characteristics and physiological functions of MSCs is presented.