Multiple Primary Melanoma Two-Year Results From a Population-Based Study
Linda Titus-Ernstoff,Ann E. Perry,Steven K. Spencer,Jennifer J. Gibson,Jiao Ding,Bernard F. Cole,Marc S. Ernstoff +6 more
TL;DR: It is confirmed that atypical moles are strongly associated with risk of multiple primary melanomas but provides little evidence that risk is influenced by pigmentary characteristics, hours of sun exposure, or benign moles.
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Abstract: Objective To assess the frequency of occurrence and risk factors for multiple primary melanoma. Design Population-based, case-control study. Setting New Hampshire. Participants Three-hundred fifty-four New Hampshire residents with a confirmed first diagnosis of cutaneous melanoma. Main Outcome Measure Diagnosis of a subsequent primary cutaneous melanoma. Results An additional melanoma occurred in 27 individuals (8%) within 2 years of their initial diagnosis, including 20 (6%) within the first postdiagnosis year. In 9 (33%) of these 27 cases, at least 1 subsequent melanoma was deeper than the first tumor. The 27 individuals with a subsequent melanoma diagnosis were classified as “cases” and were compared on the basis of risk factors to the 327 “controls” with a single melanoma diagnosis. The data indicate an inverse relation of risk of multiple primary melanomas with multiple blistering sunburns (P = .01 for the trend); the odds ratio (OR) was 0.32 (95% confidence interval [CI], 0.11-0.93) for 2 or more sunburns compared with none. The number of atypical moles was significantly related to increased risk (P = .004 for the trend). The presence of 3 or more atypical moles compared with none was associated with more than a 4-fold risk of multiple primary melanomas (OR, 4.29; 95% CI, 1.51-12.16). Conclusions Additional melanomas occur more frequently than previously shown. Our study confirms that atypical moles are strongly associated with risk of multiple primary melanomas but provides little evidence that risk is influenced by pigmentary characteristics, hours of sun exposure, or benign moles. The inverse association with blistering sunburn may reflect the influence of an unmeasured covariate.
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Citations
Single versus multiple primary melanomas: old questions and new answers.
Charlotte Hwa,Leah Price,Ilana Belitskaya-Levy,Ilana Belitskaya-Levy,Michelle W. Ma,Richard L. Shapiro,Russell S. Berman,Hideko Kamino,Farbod Darvishian,Iman Osman,Jennifer A. Stein +10 more
TL;DR: The authors compared the clinicopathologic features of patients with MPM and SPM to better characterize the differences between these 2 groups and to determine whether or not there is an inherent difference in tumor aggression.
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Clinicopathologic Features of Incident and Subsequent Tumors in Patients with Multiple Primary Cutaneous Melanomas
Rajmohan Murali,Chris Goumas,Anne Kricker,Lynn From,Klaus J. Busam,Colin B. Begg,Terence Dwyer,Stephen B. Gruber,Peter A. Kanetsky,Irene Orlow,Stefano Rosso,Nancy E. Thomas,Marianne Berwick,Richard A. Scolyer,Richard A. Scolyer,Bruce K. Armstrong +15 more
TL;DR: Thinner subsequent than first melanomas suggest earlier diagnosis, perhaps due to closer clinical scrutiny, and the association of subsequent melanomas with dysplastic nevi is consistent with the latter being risk factors or risk markers for melanoma.
Second primary melanomas: incidence and outcome.
Matthew Bower,Charles R. Scoggins,Robert C.G. Martin,Michael P. Mays,Michael J. Edwards,Douglas S. Reintgen,Merrick I. Ross,Marshall M. Urist,R. Dirk Noyes,Jeffrey J. Sussman,Lee Hagendoorn,Arnold J. Stromberg,Kelly M. McMasters +12 more
TL;DR: O Ongoing surveillance of patients with melanoma is important given that a significant number will develop additional melanoma and nonmelanoma tumors and with close follow-up, second primary melanomas are usually detected at an early stage.
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Impact of Melanoma on Patients' Lives Among 562 Survivors
Cynthia Holterhues,Darren Cornish,Lonneke V. van de Poll-Franse,Gertruud A. M. Krekels,Frans Koedijk,Danielle I.M. Kuijpers,Jan Willem Coebergh,Tamar Nijsten +7 more
- 01 Jan 2017
Abstract: OBJECTIVE
To assess the impact of melanoma on the health-related quality of life of patients from the general population up to 10 years after diagnosis and its determinants.
DESIGN
A cross-sectional Dutch population-based postal survey among patients with melanoma for the years 1998 to 2008 using the Eindhoven Cancer Registry.
MAIN OUTCOME MEASURES
The 36-Item Short-Form Health Survey (SF-36), Impact of Cancer (IOC) questionnaire and specific melanoma-related questions. The SF-36 scores of the cases were compared with normative data. Multiple linear regression models were used to identify associated factors of SF-36 and IOC scores.
RESULTS
The response rate was 80%. The mean age of the 562 respondents was 57.3 years; 62% were female, and 76% had a melanoma with a Breslow thickness of less than 2 mm. The SF-36 component scores of patients with melanoma were similar to those of the normative population. In a multiple linear regression model, stage at diagnosis, female sex, age, and comorbidity were significantly associated (P<.05) with the physical and mental component scores. Women were significantly more likely to report higher levels of both positive and negative IOC. Time since diagnosis, tumor stage, and comorbidity were significant predictors of negative IOC scores. Women seemed to adjust their sun behavior more often (54% vs 67%; P<.001) than men and were more worried about the deleterious effects of UV radiation (45% vs 66%; P<.001).
CONCLUSION
The impact of melanoma seems to be specific and more substantial in women, suggesting that they may need additional care to cope with their melanoma optimally.
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Management of in situ melanoma of the nail apparatus with functional surgery: report of 11 cases and review of the literature.
TL;DR: Nail apparatus melanoma (NAM) is a rare melanocytic neoplasm with pejorative prognosis often related to late diagnosis, and management is not well established yet.
38
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