Journal Article10.1212/WNL.42.3.506
Multifocal demyelinating motor neuropathy: cranial nerve involvement and immunoglobulin therapy
174
TL;DR: Two patients with multifocal demyelinating motor neuropathy whose symptoms improved after immunoglobulin infusion are reported, suggesting selective involvement of motor fibers in this entity.
read more
Abstract: We report two patients with multifocal demyelinating motor neuropathy whose symptoms improved after immunoglobulin infusion. Clinical signs included atrophy of the tongue and limb muscles, closely resembling that of motor neuron disease. Nerve conduction studies revealed multiple sites of motor conduction block without sensory abnormalities, suggesting selective involvement of motor fibers. Careful documentation of conduction block is required to diagnose this entity, which may be treated with immunoglobulin therapy.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Neuropatie motorie multifocali con blocco di conduzione
E. Delmont,S. Attarian +1 more
- 01 May 2024
TL;DR: Multifocal motor neuropathy with conduction blocks is an autoimmune peripheral neuropathy characterized by pure motor deficits, normal sensory function, and conduction blocks on electromyography, responsive to intravenous immunoglobulin therapy.
The physiological effect of anti-GM1 antibodies on saltatory conduction and transmembrane currents in single motor axons.
Nobuyuki Hirota,Ryuji Kaji,Hugh Bostock,Katsuro Shindo,Teruaki Kawasaki,Kotaro Mizutani,Nobuyuki Oka,Nobuo Kohara,Takahiko Saida,Jun Kimura +9 more
TL;DR: It is concluded that physiological action of the antibody alone is insufficient to explain clinically observed conduction block in human diseases.
In vitro effects of polyvalent immunoglobulin for intravenous use.
TL;DR: High dose intravenous immunoglobulin therapy is used in the treatment of a wide range of auto-immune or presumed immune-mediated neurological disorders and has probably multiple effects on induction and amplification, as well as the effector phase of the immune response.
Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies
Lotte Vlam,W. Ludo van der Pol,Elisabeth A. Cats,Dirk C. G. Straver,Sanneke Piepers,Hessel Franssen,Leonard H. van den Berg +6 more
TL;DR: The diagnostic criteria for MMN is discussed, available treatments and promising new therapeutic strategies are described, and an update on the current understanding of MMN pathogenesis is provided.
AAEM case report #30: multifocal motor neuropathy.
TL;DR: A 73‐year‐old man with a 16‐year history of fasciculations and 15 years of weakness in his right arm was diagnosed with focal motor neuron disease and treatment with high‐dose intravenous immunoglobulin was given with significant improvement in strength and partial resolution of the conduction block.
References
A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside.
Alan Pestronk,David R. Cornblath,Amjad A. Ilyas,H. Baba,Richard H. Quarles,John W. Griffin,K. Alderson,Robert N. Adams +7 more
TL;DR: 2 patients with a treatable, immune‐mediated motor polyneuropathy associated with antibodies to defined neural antigens, initially diagnosed as having lower motor neuron forms of amyotrophic lateral sclerosis are reported.
645
Multifocal demyelinating neuropathy with persistent conduction block
TL;DR: Four patients with a chronic asymmetric sensorimotor neuropathy most pronounced in the upper extremities with focal involvement of individual nerves had acute optic neuritis, indicating that the disorder was not always restricted to the peripheral nervous system.
503
Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice
TL;DR: This 672-page volume written by a single author contains 26 chapters in seven parts and three appendices and is intended for practicing electromyographers and all those concerned with electrodiagnostic tests in clinical practice.
204
Conduction block in clinical practice
David R. Cornblath,Austin J. Sumner,J. Daube,R. W. Gilliat,William F. Brown,Gareth Parry,J. W. Albers,R. G. Miller,J. Petajan +8 more
TL;DR: The difficulties in recognizing partial conduction block in motor fibers using conventional electromyographic techniques using conventional electromyographic techniques are discussed.
177