Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.

TL;DR: Genotyping of CYP3A5, ACTN4, and MYH9 polymorphisms may be helpful for better guiding tacrolimus dosing in pediatric patients with refractory NS.

TL;DR: A meta-analysis for the including studies about the pharmacokinetics of tacrolimus and ABCB1 C3435T SNP obtained several significant associations; however, the correlations were not steady at different post-transplantation times.

TL;DR: A predictive model is created that will be able to determine the relative expression of the ABCB1 gene in the blood and the correlation with the expression in the brain, liver, kidney, duodenum, jejunum, ileum and colon.

TL;DR: ETT may present as a solitary abdominal wall lesion and microsatellite genotyping could facilitate the determination of its gestational origin, and more studies are required to provide mechanistic insights into the chemoresistance of ETT.

TL;DR: A significant correlation of a polymorphism in exon 26 (C3435T) of MDR-1 with expression levels and function is observed and this polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of M DR-1.

TL;DR: Allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P‐glycoprotein function.

TL;DR: Some synonymous mutations in the human DRD2 have functional effects and suggest a novel genetic mechanism, calling into question some assumptions made about synonymous variation in molecular population genetics and gene-mapping studies of diseases with complex inheritance, and indicate that synonymous variation can have effects of potential pathophysiological and pharmacogenetic importance.

TL;DR: SNPs in MDR1 in relation to population frequencies, drug levels, and phenotypes are outlined and issues relating to M DR1 haplotypes, environmental factors, and study design, as potential confounding factors of the observed MDR 1 polymorphism effect in vivo, are discussed.